Evidence map›Paper›PMID 27062518›Full record

ArticleMagnetic resonance in medicine2017

Magnetic barcode imaging for contrast agents.

Andy H Hung, Laura M Lilley, Fengqin Hu, Victoria S R Harrison, Thomas J Meade

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andy H HungDepartment of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Northwestern University, Evanston, Illinois, USA.
Laura M LilleyDepartment of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Northwestern University, Evanston, Illinois, USA.
Fengqin HuCollege of Chemistry, Beijing Normal University, Beijing, China.
Victoria S R HarrisonDepartment of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Northwestern University, Evanston, Illinois, USA.
Thomas J MeadeDepartment of Chemistry, Molecular Biosciences, Neurobiology, Biomedical Engineering, and Radiology, Northwestern University, Evanston, Illinois, USA.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008152 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARDEHALI, HOSSEIN · 1987 to 2021
$24.0M
Theranostic Magnetic Nanostructures for the Molecular Imaging of CancerU54CA151880 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MIRKIN, CHAD A. · 2010 to 2014
$11.5M
q-Modulated Magnetic Resonance Imaging Contrast AgentsR01EB005866 · NIBIB · NORTHWESTERN UNIVERSITY · PI MEADE, THOMAS J · 2005 to 2013
$2.2M
Steroid-Based Contrast Agents for Magnetic Resonance Imaging of Endocrine DiseaseR01EB014806 · NIBIB · NORTHWESTERN UNIVERSITY · PI MEADE, THOMAS J · 2012 to 2015
$1.4M
Zeiss PALM Laser Capture Microdissection SystemS10RR025624 · NCRR · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHEW, TENG-LEONG · 2009 to 2009
$252k
NCI NIH HHS P30 CA060553NCI NIH HHS U54 CA151880NCRR NIH HHS S10 RR025624NIBIB NIH HHS R01 EB005866NIBIB NIH HHS R01 EB014806NIGMS NIH HHS T32 GM008152
6 · The paper itself

Abstract

purposeTo demonstrate a new MR imaging approach that unambiguously identifies and quantitates contrast agents based on intrinsic agent properties such as r

methodsTargeted and bioresponsive contrast agents were imaged in agarose phantoms to generate T

resultsMBI allowed the quantitative interpretation of intensities, removed confounding backgrounds, enabled contrast agent multiplexing, and unambiguously detected the activation and binding states of bioresponsive and targeted contrast agents.

conclusionMBI has the potential to overcome significant limitations in the interpretation, quantitation, and multiplexing of contrast enhancement by MR imaging probes. Magn Reson Med 77:970-978, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

Indexed as

AlgorithmsMolecular Probe TechniquesContrast MediaMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMolecular ImagingPhantoms, ImagingReproducibility of ResultsSensitivity and SpecificityContrast Mediacontrast agentmachine learningmagnetic resonance imagingmolecular imaging

Identifiers

PMID27062518
PMCPMC5055837

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.