ArticleJournal of veterinary internal medicine2016
A Prospective, Placebo-Controlled Pilot Evaluation of the Effect of Omeprazole on Serum Calcium, Magnesium, Cobalamin, Gastrin Concentrations, and Bone in Cats.
Article in Journal of veterinary internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Prevalence of Gastroesophageal Reflux in Cats During Anesthesia and Effect of Omeprazole on Gastric pH.Journal of veterinary internal medicine · 2017Trial
- Repeated Famotidine Administration Results in a Diminished Effect on Intragastric pH in Dogs.Journal of veterinary internal medicine · 2017Trial
- Rational use of gastroprotectants in cats: An evidence-based approach.Journal of feline medicine and surgery · 2024Review
- Prospective Randomized Controlled Clinical Trial of the Long-Term Effects of Omeprazole on Healthy Dogs.Animals : an open access journal from MDPI · 2024Article
- Prevalence and appropriateness of omeprazole prescription in dogs at a veterinary teaching hospital before and after the publication of the ACVIM consensus statement on the rational administration of gastrointestinal protectants.Frontiers in veterinary science · 2024Article
- Evaluation of gastroprotectant administration in hospitalized cats in a tertiary referral hospital.Journal of feline medicine and surgery · 2023Article
- Evaluation of a long-acting injectable formulation of omeprazole in healthy dogs.Journal of veterinary internal medicine · 2022Article
- Gastrin and the Moderate Hypergastrinemias.International journal of molecular sciences · 2021Review
- Survey-Based Analysis of Current Trends for Prescribing Gastrointestinal Protectants among Small-Animal General Practitioners in Portugal.Veterinary sciences · 2021Article
- Comparative analysis of the effect of PO administered acid suppressants on gastric pH in healthy cats.Journal of veterinary internal medicine · 2020Article
- Electrolyte disturbances in children receiving omeprazole for gastroesophageal reflux disease.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Article
- Pharmacological Effects and Toxicogenetic Impacts of Omeprazole: Genomic Instability and Cancer.Oxidative medicine and cellular longevity · 2020Review
- The frequency of oral famotidine administration influences its effect on gastric pH in cats over time.Journal of veterinary internal medicine · 2019Article
- ACVIM consensus statement: Support for rational administration of gastrointestinal protectants to dogs and cats.Journal of veterinary internal medicine · 2018Article
- Retrospective analysis of the effect of acid-suppressant therapy on clinicopathologic parameters of cats with chronic kidney disease.Journal of feline medicine and surgery · 2018Article
- Omeprazole Minimally Alters the Fecal Microbial Community in Six Cats: A Pilot Study.Frontiers in veterinary science · 2018Article
- Evaluation of Gastric pH and Serum Gastrin Concentrations in Cats with Chronic Kidney Disease.Journal of veterinary internal medicine · 2017Article
- Gastric pH and serum gastrin concentration in age-matched healthy dogs and dogs with chronic kidney disease.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic proton pump inhibitor administration has been associated with electrolyte and cobalamin deficiency, disrupted bone homeostasis, hypergastrinemia, and rebound acid hypersecretion in humans. It is unknown if this occurs in cats.
objectivesProlonged oral omeprazole results in altered bone mineral density or content, serum calcium, magnesium, cobalamin, and gastrin concentrations in healthy cats. ANIMALS: Six healthy adult DSH cats.
methodsIn a within subjects, before and after design, cats received placebo followed by omeprazole (0.83-1.6 mg/kg PO q12h) for 60 days each. Analysis of serum calcium, magnesium, cobalamin, and gastrin concentrations was performed on days 0, 30, and 60. Bone density and content were evaluated on days 0 and 60 of each intervention. Continuous data were analyzed using a two-way ANOVA (α = 0.006). On day 60 of omeprazole administration, continuous intragastric pH monitoring was performed in 2 cats to evaluate the effects of abrupt withdrawal of omeprazole.
resultsNo significant changes were detected between treatments for any variables, except serum gastrin, which was significantly higher during omeprazole treatment in comparison to placebo (P = 0.002). Evidence of gastric hyperacidity was seen in both cats in which intragastric pH monitoring was performed following cessation of omeprazole. CONCLUSIONS AND CLINICAL IMPORTANCE: Although further studies with larger populations of cats will be needed to draw any definitive conclusions, these preliminary results suggest that prolonged PPI treatment results in hypergastrinemia and abrupt PPI withdrawal might result in RAH in cats.
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