ArticleBritish journal of clinical pharmacology2016
Ventricular tachyarrhythmia and sudden cardiac death with domperidone use in Parkinson's disease.
Article in British journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02500108 (Domperidone Use in Parkinson's Disease and Risk of Sudden Cardiac Death), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Domperidone Use in Parkinson's Disease and Risk of Sudden Cardiac Death
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Canadian guideline for Parkinson disease.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2019Guideline
- Practical use of apomorphine infusion in Parkinson's disease: lessons from the TOLEDO study and clinical experience.Journal of neural transmission (Vienna, Austria : 1996) · 2023Trial
- Safety, Pharmacokinetics, and Pharmacodynamics of Trazpiroben (TAK-906), a Novel Selective DClinical pharmacology in drug development · 2021Trial
- Gastroparesis in Parkinson's disease: Diagnostic and clinical implications for optimizing pharmacological treatment.Journal of Parkinson's disease · 2026Review
- Device aided therapies in Parkinson disease: an expert view on apomorphine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- Use and misuse of domperidone in patients living with Parkinson disease in France.Fundamental & clinical pharmacology · 2025Article
- Anesthetic Considerations for Cataract Surgery in Patients with Parkinson's Disease: A Narrative Review.Anesthesiology and pain medicine · 2023Review
- Drug-induced Sudden Death: A Scoping Review.Current drug safety · 2023Article
- Management of dysphagia and gastroparesis in Parkinson's disease in real-world clinical practice - Balancing pharmacological and non-pharmacological approaches.Frontiers in aging neuroscience · 2022Review
- Cardiac Changes in Parkinson's Disease: Lessons from Clinical and Experimental Evidence.International journal of molecular sciences · 2021Review
- Prevalence of QTc Prolongation in Patients with Parkinson's Disease. Assessment of the Effects of Drugs, Clinical Risk Factors and Used Correction Formula.Journal of clinical medicine · 2021Article
- Parkinson disease and the gut: new insights into pathogenesis and clinical relevance.Nature reviews. Gastroenterology & hepatology · 2020Review
- Therapeutic Strategies to Treat or Prevent Off Episodes in Adults with Parkinson's Disease.Drugs · 2020Review
- The mitochondrial calcium uniporter: a new therapeutic target for Parkinson's disease-related cardiac dysfunctions?Clinics (Sao Paulo, Brazil) · 2020Article
- Apomorphine for Parkinson's Disease: Efficacy and Safety of Current and New Formulations.CNS drugs · 2019Review
- Cardiovascular alterations in rats with Parkinsonism induced by 6-OHDA and treated with Domperidone.Scientific reports · 2019Article
- Increased risk of all-cause mortality associated with domperidone use in Parkinson's patients: a population-based cohort study in the UK.British journal of clinical pharmacology · 2018Article
- Sudden unexpected death in Parkinson's disease (SUDPAR): a review of publications since the decade of the brain.Clinics (Sao Paulo, Brazil) · 2017Article
- Prokinetics in the Management of Functional Gastrointestinal Disorders.Current gastroenterology reports · 2017Review
- Ventricular tachyarrhythmia and sudden cardiac death with domperidone use in Parkinson's disease.British journal of clinical pharmacology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 9 institutions in 1 country.
Funding
Abstract
aimDomperidone is preferentially used over other antiemetic agents to treat digestive symptoms in Parkinson's disease (PD). Concerns have been raised regarding an increased risk of ventricular tachyarrhythmia and sudden cardiac death (VT/SCD) associated with domperidone in the general population. However, the risk in PD is unknown.
methodsWe conducted a multicentre retrospective cohort study using administrative databases from seven Canadian provinces and the UK Clinical Practice Research Datalink. Using a nested case-control analysis, we estimated the rate ratios (RRs) of VT/SCD associated with domperidone use compared to no use in patients newly-diagnosed with PD. VT/SCD events were identified using administrative medical records and vital statistics with a manual review of all potential cases. Meta-analytic methods were used to estimate overall effects across sites.
resultsAmong 214 962 patients with PD, 2907 cases of VT/SCD were identified during 886 581 person-years of follow-up (incidence rate 3.28 per 1000 persons per year). Current use of domperidone was associated with a non-statistically significant 22% increased risk of VT/SCD (RR 1.22; 95% CI 0.99-1.50) compared with no use. The risk was significantly elevated in those with a history of cardiovascular disease (RR 1.38; 95% CI 1.07-1.78), but not in those without (RR 1.21; 95% CI 0.81-1.81). Dose and duration of use did not affect the magnitude of the risk.
conclusionDomperidone use may increase the risk of VT/SCD in patients with PD, particularly those with a history of cardiovascular disease. This risk may be underestimated because of imprecision in identifying VT/SCD events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.