ReviewPlant biology (Stuttgart, Germany)2016
CAX-ing a wide net: Cation/H(+) transporters in metal remediation and abiotic stress signalling.
Review in Plant biology (Stuttgart, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed.
- Regulatory insights underlying apple to cold stress.Horticulture research · 2026Article
- Integrated Multi-Omics Analysis Revealed the Synergistic Regulatory Mechanisms of Salt Tolerance in Soybean (Kefeng 1).Plants (Basel, Switzerland) · 2026Article
- Identification of the cation/H+ exchanger genes in peanut and functional analysis ofFrontiers in plant science · 2026Article
- CAX1 beyond calcium transport: evidence for a transport-independent regulatory module in plants.Frontiers in plant science · 2026Review
- A modular fragment of Arabidopsis cation exchanger 1 (CAX1) reveals structural constraints on assembly.Plant molecular biology · 2025Article
- Evolution and diversification of CaBMC plant biology · 2025Article
- An N-terminal transport-deficient module of CATION EXCHANGER1 is sufficient to trigger anoxia stress responses.Plant physiology · 2025Article
- Cellular calcium homeostasis and regulation of its dynamic perturbation.Quantitative plant biology · 2025Review
- Zinc Oxide Nanoparticles Alleviate Salt Stress in Cotton (Life (Basel, Switzerland) · 2024Article
- Functional differentiation and genetic diversity of rice cation exchanger (CAX) genes and their potential use in rice improvement.Scientific reports · 2024Article
- Golgi apparatus-localized CATION CALCIUM EXCHANGER4 promotes osmotolerance of Arabidopsis.Plant physiology · 2024Article
- Cytosolic alkalinization in guard cells: an intriguing but interesting event during stomatal closure that merits further validation of its importance.Frontiers in plant science · 2024Review
- Article
- Plants' molecular behavior to heavy metals: from criticality to toxicity.Frontiers in plant science · 2024Review
- Mechanically-primed voltage-gated proton channels from angiosperm plants.Nature communications · 2023Article
- Reactive oxygen species- and nitric oxide-dependent regulation of ion and metal homeostasis in plants.Journal of experimental botany · 2023Article
- Genome-Wide Identification ofGenes · 2023Article
- Spraying Zinc Sulfate to Reveal the Mechanism through the Glutathione Metabolic Pathway Regulates the Cadmium Tolerance of Seashore Paspalum (Plants (Basel, Switzerland) · 2023Article
- The Potential of CRISPR/Cas Technology to Enhance Crop Performance on Adverse Soil Conditions.Plants (Basel, Switzerland) · 2023Review
- Tobacco as an efficient metal accumulator.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cation/proton exchangers (CAXs) are a class of secondary energised ion transporter that are being implicated in an increasing range of cellular and physiological functions. CAXs are primarily Ca(2+) efflux transporters that mediate the sequestration of Ca(2+) from the cytosol, usually into the vacuole. Some CAX isoforms have broad substrate specificity, providing the ability to transport trace metal ions such as Mn(2+) and Cd(2+) , as well as Ca(2+) . In recent years, genomic analyses have begun to uncover the expansion of CAXs within the green lineage and their presence within non-plant species. Although there appears to be significant conservation in tertiary structure of CAX proteins, there is diversity in function of CAXs between species and individual isoforms. For example, in halophytic plants, CAXs have been recruited to play a role in salt tolerance, while in metal hyperaccumulator plants CAXs are implicated in cadmium transport and tolerance. CAX proteins are involved in various abiotic stress response pathways, in some cases as a modulator of cytosolic Ca(2+) signalling, but in some situations there is evidence of CAXs acting as a pH regulator. The metal transport and abiotic stress tolerance functions of CAXs make them attractive targets for biotechnology, whether to provide mineral nutrient biofortification or toxic metal bioremediation. The study of non-plant CAXs may also provide insight into both conserved and novel transport mechanisms and functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.