ArticleAging cell2016
Characterization of the direct targets of FOXO transcription factors throughout evolution.
Article in Aging cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
119 citing papers in PubMed, 187 citations in OpenAlex.
- Loss of intestinal Akt elicits rapid mortality via intestinal damage which is rescued by mTORC1 activation.Nature communications · 2026Article
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- Functional annotation of insulin-responsive genes in human adipocytes reveals PLCXD1 as a lipid storage regulator.Nature communications · 2026Article
- Temporal Proteomic Profiling Reveals Tissue-Specific and Coordinated Metabolic Reprogramming in Skeletal Muscle and Liver during Prolonged Fasting.Proteomics · 2026Article
- Astrocytic HMGCR-Mediated Cholesterol Alleviated Parkinson's Disease Phenotypes by Inhibiting NF-κB Neuroinflammation.Molecular neurobiology · 2026Article
- TACI regulates marginal zone B cell development.The Journal of experimental medicine · 2026Article
- 14-3-3ζ interacts with DNA-binding domain of FOXO3a and competitively dissociates DNA by dual-motif tethering.Nature communications · 2026Article
- The future of Forkhead box O transcription factors.The Biochemical journal · 2026Review
- Targeting IL6-Edn1-FoxO1 axis enables lung growth in mechanically ventilated newborn mice.The European respiratory journal · 2025Article
- Impaired ketogenesis in Leydig Cells drives testicular aging.Nature communications · 2025Article
- Autophagy mediated by ROS-AKT-FoxO pathway is required for intestinal regeneration in echinoderms.Cell communication and signaling : CCS · 2025Article
- FOXOs and their roles in acute and chronic neurological disorders.Frontiers in molecular biosciences · 2025Review
- Insulin Resistance Is a Modifying Factor for Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Measuring FOXO Nuclear Shuttling Dynamics by Fluorescence Microscopy.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Reporter Gene Assays to Measure FOXO-Specific Transcriptional Activity.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Hypoxia-reoxygenation Extends the Lifespan ofCurrent aging science · 2025Article
- FOXO-regulated OSER1 reduces oxidative stress and extends lifespan in multiple species.Nature communications · 2024Article
- Whole-Genome Resequencing Reveals Signatures of Adaptive Evolution inAnimals : an open access journal from MDPI · 2024Article
- Spatial genomic, biochemical and cellular mechanisms underlying meningioma heterogeneity and evolution.Nature genetics · 2024Article
- FOXO1 regulates expression of Neurod4 in the pituitary gland.Molecular and cellular endocrinology · 2024Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
FOXO transcription factors (FOXOs) are central regulators of lifespan across species, yet they also have cell-specific functions, including adult stem cell homeostasis and immune function. Direct targets of FOXOs have been identified genome-wide in several species and cell types. However, whether FOXO targets are specific to cell types and species or conserved across cell types and throughout evolution remains uncharacterized. Here, we perform a meta-analysis of direct FOXO targets across tissues and organisms, using data from mammals as well as Caenorhabditis elegans and Drosophila. We show that FOXOs bind cell type-specific targets, which have functions related to that particular cell. Interestingly, FOXOs also share targets across different tissues in mammals, and the function and even the identity of these shared mammalian targets are conserved in invertebrates. Evolutionarily conserved targets show enrichment for growth factor signaling, metabolism, stress resistance, and proteostasis, suggesting an ancestral, conserved role in the regulation of these processes. We also identify candidate cofactors at conserved FOXO targets that change in expression with age, including CREB and ETS family factors. This meta-analysis provides insight into the evolution of the FOXO network and highlights downstream genes and cofactors that may be particularly important for FOXO's conserved function in adult homeostasis and longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.