Trial reportThe Journal of physiology2016
Evidence of a broad histamine footprint on the human exercise transcriptome.
Trial report in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Transcriptomic profiling of skeletal muscle adaptations to exercise and inactivity.Nature communications · 2020Pooled it
- Histamine-receptor blockade does not influence the heavy-severe domain boundary and time to task failure in the severe domain during cycling exercise in adults.Physiological reports · 2025Trial
- Histamine is a molecular transducer of adaptation to endurance exercise training in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Trial
- Histamine-Receptor Antagonists Slow 10-km Cycling Performance in Competitive Cyclists.Medicine and science in sports and exercise · 2019Trial
- Mast cell degranulation and de novo histamine formation contribute to sustained postexercise vasodilation in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- A single dose of histamine-receptor antagonists before downhill running alters markers of muscle damage and delayed-onset muscle soreness.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- The effects of cold water immersion and active recovery on inflammation and cell stress responses in human skeletal muscle after resistance exercise.The Journal of physiology · 2017Trial
- Article
- Evidence of histamine release in response to both aerobic and resistance exercise: histamine metabolites as biomarkers.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Lactate in Anaphylaxis: 100 Years On.Sports medicine (Auckland, N.Z.) · 2025Review
- Exercise-induced CLCF1 attenuates age-related muscle and bone decline in mice.Nature communications · 2025Article
- Specific histamine regulating activity of surface-modified yeast vacuoles by histamine- binding protein and its immune-enhancing effect.Microbial biotechnology · 2022Article
- Acute heat exposure protects against endothelial ischemia-reperfusion injury in aged humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- The effect of local passive heating on skeletal muscle histamine concentration: implications for exercise-induced histamine release.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Shear stress induced by acute heat exposure is not obligatory to protect against endothelial ischemia-reperfusion injury in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Histamine HScience advances · 2021Article
- Transcriptomic Signatures and Upstream Regulation in Human Skeletal Muscle Adapted to Disuse and Aerobic Exercise.International journal of molecular sciences · 2021Article
- Skeletal Muscle Hyperemia: A Potential Bridge Between Post-exercise Hypotension and Glucose Regulation.Frontiers in physiology · 2021Review
- The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations.Frontiers in physiology · 2021Review
- Effect of endoplasmic reticulum stress on endothelial ischemia-reperfusion injury in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
key pointsHistamine is a primordial signalling molecule, capable of activating cells in an autocrine or paracrine fashion via specific cell surface receptors, in a variety of pathways that probably predate its more recent role in innate and adaptive immunity. Although histamine is normally associated with pathological conditions or allergic and anaphylactic reactions, it may contribute beneficially to the normal changes that occur within skeletal muscle during the recovery from exercise. We show that the human response to exercise includes an altered expression of thousands of protein-coding genes, and much of this response appears to be driven by histamine. Histamine may be an important molecular transducer contributing to many of the adaptations that accompany chronic exercise training. ABSTRACT: Histamine is a primordial signalling molecule, capable of activating cells in an autocrine or paracrine fashion via specific cell surface receptors. In humans, aerobic exercise is followed by a post-exercise activation of histamine H1 and H2 receptors localized to the previously exercised muscle. This could trigger a broad range of cellular adaptations in response to exercise. Thus, we exploited RNA sequencing to explore the effects of H1 and H2 receptor blockade on the exercise transcriptome in human skeletal muscle tissue harvested from the vastus lateralis. We found that exercise exerts a profound influence on the human transcriptome, causing the differential expression of more than 3000 protein-coding genes. The influence of histamine blockade post-exercise was notable for 795 genes that were differentially expressed between the control and blockade condition, which represents >25% of the number responding to exercise. The broad histamine footprint on the human exercise transcriptome crosses many cellular functions, including inflammation, vascular function, metabolism, and cellular maintenance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.