Evidence map›Paper›PMID 27061263›Full record

ArticleEuropean urology2016

Circulating Folate and Vitamin B

Alison J Price, Ruth C Travis, Paul N Appleby, Demetrius Albanes, Aurelio Barricarte Gurrea, Tone Bjørge, H Bas Bueno-de-Mesquita, Chu Chen, Jenny Donovan, Randi Gislefoss and 24 more

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In one paragraph

Article in European urology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 73 citations in OpenAlex.

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  11. Association of serum folate concentrations with the mortality of cancer: a prospective cohort study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

34 authors at 20 institutions in 12 countries.

Alison J PriceCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK; London School of Hygiene and Tropical Medicine, London, UK. Electronic address: alison.price@ceu.ox.ac.uk.
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Paul N ApplebyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Demetrius AlbanesNutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD, USA.
Aurelio Barricarte GurreaNavarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Tone BjørgeDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Cancer Registry of Norway, Oslo, Norway.
H Bas Bueno-de-MesquitaDepartment for Determinants of Chronic Diseases, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands; Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK; Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Chu ChenPublic Health Sciences Division, Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jenny DonovanSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Randi GislefossCancer Registry of Norway, Oslo, Norway; Institute of Population-based research, Montebello, Oslo, Norway.
Gary GoodmanPublic Health Sciences Division, Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Marc GunterDepartment of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.
Freddie C HamdyNuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, UK.
Mattias JohanssonInternational Agency for Research on Cancer, Lyon, France; Department of Biobank Research, Umeå University, Umeå, Sweden.
Irena B KingDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
Tilman KühnDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Satu MännistöDepartment of Health, National Institute for Health and Welfare, Helsinki, Finland.
Richard M MartinSchool of Social and Community Medicine, University of Bristol, Bristol, UK; Medical Research Council/University of Bristol Integrative Epidemiology Unit, University of Bristol, Bristol, UK; National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, UK.
Klaus MeyerBevital AS, Bergen, Norway.
David E NealDepartment of Oncology, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
Marian L NeuhouserPublic Health Sciences Division, Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Ottar NygårdDepartment of Clinical Science, University of Bergen, Bergen, Norway; Department of Heart Disease, Haukeland University Hospital, Bergen, Norway.
Par StattinDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.
Grethe S TellDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Antonia TrichopoulouWHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens, Greece; Hellenic Health Foundation, Athens, Greece.
Rosario TuminoCancer Registry and Histopathology Unit, "Civic - M.P. Arezzo" Hospital, ASP Ragusa, Ragusa, Italy.
Per Magne UelandDepartment of Clinical Science, University of Bergen, Bergen, Norway.
Arve UlvikBevital AS, Bergen, Norway.
Stefan de VogelDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
Stein Emil VollsetDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Norwegian Institute of Public Health, Bergen, Norway.
Stephanie J WeinsteinNutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda MD, USA.
Timothy J KeyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Naomi E AllenClinical trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Clinical Medicine, University of Oxford, UK.
Endogenous Hormones, Nutritional Biomarkers, and Prostate Cancer Collaborative Group
University of Bergen · NOUniversity of Oxford · GBFred Hutch Cancer Center · USBevital (Norway) · NODivision of Cancer Epidemiology and GeneticsUmeå University · SEAddenbrooke's Hospital · GBAzienda Usl 8 Arezzo · ITCancer Registry of Norway · NOCentre International de Recherche sur le Cancer · FRCentro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESFinnish Institute for Health and Welfare · FIGerman Cancer Research Center · DEHellenic Health Foundation · GRImperial College London · GBJohn Radcliffe Hospital · GBLondon School of Hygiene & Tropical Medicine · GBNational Institute for Health Research · GBUniversity Medical Center Utrecht · NLUniversity of Bristol · GB

Funding

THE CAROTENE AND RETINOL EFFICACY TRIAL (CARET)U01CA063673 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GOODMAN, GARY E · 1994 to 2006
$13.0M
INFRASRUCTURE SUPPORT AND DATA ENHANCEMENTS FOR THE CARET BIOREPOSITORYUM1CA167462 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GOODMAN, GARY E · 2013 to 2017
$2.8M
Cancer Research UK 14136Cancer Research UK 16491Cancer Research UK 19169Cancer Research UK 19170Cancer Research UK A19169Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MR/M012190/1Medical Research Council MR/N003284/1NCI NIH HHS U01 CA063673NCI NIH HHS UM1 CA167462World Health Organization 001
6 · The paper itself

Abstract

backgroundFolate and vitamin B

objectiveTo investigate the associations between circulating folate and vitamin B DESIGN, SETTING, AND

participantsA study was performed with a nested case-control design based on individual participant data from six cohort studies including 6875 cases and 8104 controls; blood collection from 1981 to 2008, and an average follow-up of 8.9 yr (standard deviation 7.3). Odds ratios (ORs) of incident PCa by study-specific fifths of circulating folate and vitamin B OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Incident PCa and subtype by stage and grade. RESULTS AND LIMITATIONS: Higher folate and vitamin B

conclusionsThe association between higher folate concentration and risk of high-grade disease, not evident for low-grade disease, suggests a possible role for folate in the progression of clinically relevant PCa and warrants further investigation. PATIENT SUMMARY: Folate, a vitamin obtained from foods and supplements, is important for maintaining cell health. In this study, however, men with higher blood folate levels were at greater risk of high-grade (more aggressive) prostate cancer compared with men with lower folate levels. Further research is needed to investigate the possible role of folate in the progression of this disease.

Indexed as

AgedCase-Control StudiesCohort StudiesFolic AcidHexetidineHumansLogistic ModelsMaleMiddle AgedOdds RatioProstatic NeoplasmsRiskVitamin B 12Folic AcidHexetidineVitamin B 12FolateHigh gradePooled data meta-analysisProspective cohortProstate cancerVitamin B(12)

Identifiers

PMID27061263
PMCPMC5094800
OpenAlexW2334889994

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.