Evidence map›Paper›PMID 27061249›Full record

Trial reportThe Journal of allergy and clinical immunology2016

Respiratory syncytial virus and rhinovirus severe bronchiolitis are associated with distinct nasopharyngeal microbiota.

Jonathan M Mansbach, Kohei Hasegawa, David M Henke, Nadim J Ajami, Joseph F Petrosino, Chad A Shaw, Pedro A Piedra, Ashley F Sullivan, Janice A Espinola, Carlos A Camargo

Abstract readClinical TrialLetterMulticenter Study
In one paragraph

Trial report in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. [Clinical effect of azithromycin adjuvant therapy in children with bronchiolitis: a systematic review and Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019
    Pooled it
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  13. Effect ofEClinicalMedicine · 2022
    Article
  14. Article
  15. Proteome signature difference between respiratory viruses is associated with severity of bronchiolitis.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021
    Article
  16. Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jonathan M MansbachDepartment of Medicine, Boston Children's Hospital, Boston, Mass. Electronic address: jonathan.mansbach@childrens.harvard.edu.
Kohei HasegawaDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, Mass.
David M HenkeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Tex.
Nadim J AjamiDepartment of Molecular Virology and Microbiology, Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, Tex.
Joseph F PetrosinoDepartment of Molecular Virology and Microbiology, Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, Tex.
Chad A ShawDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, Tex.
Pedro A PiedraDepartment of Molecular Virology and Microbiology, Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, Tex; Department of Molecular Virology and Microbiology and Pediatrics, Baylor College of Medicine, Houston, Tex.
Ashley F SullivanDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, Mass.
Janice A EspinolaDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, Mass.
Carlos A CamargoDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, Mass; Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Mass.

Funding

Prospective Cohort Study of Severe Bronchiolitis and Risk of Recurrent WheezingU01AI087881 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CAMARGO, CARLOS ARTURO · 2011 to 2016
$6.2M
Prospective Multicenter Study of Bronchiolitis Admissions: Etiology & DispositionU01AI067693 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI CAMARGO, CARLOS ARTURO · 2007 to 2010
$3.6M
Viral persistence & the microbiome in bronchiolitis and risk of recurrent wheezeR01AI108588 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI MANSBACH, JONATHAN M · 2015 to 2018
$2.9M
Cytokines & transcriptomes in rhinovirus bronchiolitis and risk of incident asthmaR21HL129909 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HASEGAWA, KOHEI · 2015 to 2016
$506k
NHLBI NIH HHS R21 HL129909NIAID NIH HHS R01 AI108588NIAID NIH HHS U01 AI067693NIAID NIH HHS U01 AI087881
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

MicrobiotaRespiratory Syncytial Virus, HumanRhinovirusBronchiolitis, ViralFemaleHumansInfantInfant, NewbornMaleNasal CavityPharynxPicornaviridae InfectionsRespiratory Syncytial Virus Infections

Identifiers

PMID27061249
PMCPMC4899255

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.