ArticleAngewandte Chemie (International ed. in English)2016
Designer Micelles Accelerate Flux Through Engineered Metabolism in E. coli and Support Biocompatible Chemistry.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Advances in integrating microbial metabolism with catalytic systems.Nature chemical biology · 2025Review
- A biocompatible Lossen rearrangement in Escherichia coli.Nature chemistry · 2025Article
- Article
- Article
- Palladium Nanoparticles fromJACS Au · 2022Article
- Tyramine Derivatives Catalyze the Aldol Dimerization of Butyraldehyde in the Presence of Escherichia coli.Chembiochem : a European journal of chemical biology · 2022Article
- Micellar catalysis of the Suzuki Miyaura reaction using biogenic Pd nanoparticles fromGreen chemistry : an international journal and green chemistry resource : GC · 2021Article
- Exporting Metal-Carbene Chemistry to Live Mammalian Cells: Copper-Catalyzed Intracellular Synthesis of Quinoxalines Enabled by N-H Carbene Insertions.Angewandte Chemie (International ed. in English) · 2021Article
- Interfacing non-enzymatic catalysis with living microorganisms.RSC chemical biology · 2021Review
- Microbial synthesis of vanillin from waste poly(ethylene terephthalate).Green chemistry : an international journal and green chemistry resource : GC · 2021Article
- Harnessing biocompatible chemistry for developing improved and novel microbial cell factories.Microbial biotechnology · 2020Review
- A Screening Platform to Identify and Tailor Biocompatible Small-Molecule Catalysts.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Chemo-enzymatic cascades to produce cycloalkenes from bio-based resources.Nature communications · 2019Article
- Bridging the gap between transition metal- and bio-catalysis via aqueous micellar catalysis.Nature communications · 2019Article
- Efficient production of red Monascus pigments with single non-natural amine residue by in situ chemical modification.World journal of microbiology & biotechnology · 2019Article
- Biocatalytic activity of Monascus mycelia depending on physiology and high sensitivity to product concentration.AMB Express · 2017Article
- Crossing boundaries: the importance of cellular membranes in industrial biotechnology.Journal of industrial microbiology & biotechnology · 2017Review
- DNA-Accelerated Catalysis of Carbene-Transfer Reactions by a DNA/Cationic Iron Porphyrin Hybrid.Angewandte Chemie (International ed. in English) · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Synthetic biology has enabled the production of many value-added chemicals via microbial fermentation. However, the problem of low product titers from recombinant pathways has limited the utility of this approach. Methods to increase metabolic flux are therefore critical to the success of metabolic engineering. Here we demonstrate that vitamin E-derived designer micelles, originally developed for use in synthetic chemistry, are biocompatible and accelerate flux through a styrene production pathway in Escherichia coli. We show that these micelles associate non-covalently with the bacterial outer-membrane and that this interaction increases membrane permeability. In addition, these micelles also accommodate both heterogeneous and organic-soluble transition metal catalysts and accelerate biocompatible cyclopropanation in vivo. Overall, this work demonstrates that these surfactants hold great promise for further application in the field of synthetic biotechnology, and for expanding the types of molecules that can be readily accessed from renewable resources via the combination of microbial fermentation and biocompatible chemistry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.