ArticleDevelopmental biology2016
An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull.
Article in Developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Mesenchymal-derived neural progenitors underlie localbioRxiv : the preprint server for biology · 2026Article
- On the Maxillofacial Development of Mice, Mus musculus.Journal of morphology · 2025Article
- Extracellular volume expansion drives vertebrate axis elongation.Current biology : CB · 2025Article
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- Bone morphogenetic protein signaling pathway- Ethanol interactions disrupt palate formation independent of gata3.Reproductive toxicology (Elmsford, N.Y.) · 2025Article
- Insights into Craniofacial Development and Anomalies: Exploring Fgf Signaling in Zebrafish Models.Current osteoporosis reports · 2024Review
- Zebrafish raptor mutation inhibits the activity of mTORC1, inducing craniofacial defects due to autophagy-induced neural crest cell death.Development (Cambridge, England) · 2024Article
- Article
- High-throughput detection of craniofacial defects in fluorescent zebrafish.Birth defects research · 2023Article
- FGF9 Promotes Expression of HAS2 in Palatal Elevation via the Wnt/β-Catenin/TCF7L2 Pathway.Biomolecules · 2022Article
- Embryonic Nicotine Exposure Disrupts Adult Social Behavior and Craniofacial Development in Zebrafish.Toxics · 2022Article
- Genetic Parameter Estimation and Genome-Wide Association Analysis of Social Genetic Effects on Average Daily Gain in Purebreds and Crossbreds.Animals : an open access journal from MDPI · 2022Article
- On the horizon: Hedgehog signaling to heal broken bones.Bone research · 2022Review
- A Neural Crest-specific Overexpression Mouse Model Reveals the Transcriptional Regulatory Effects of Dlx2 During Maxillary Process Development.Frontiers in physiology · 2022Article
- Exposure to ethanol leads to midfacial hypoplasia in a zebrafish model of FASD via indirect interactions with the Shh pathway.BMC biology · 2021Article
- Variation in phenotypes from a Bmp-Gata3 genetic pathway is modulated by Shh signaling.PLoS genetics · 2021Article
- Article
- FGF/FGFR signaling in health and disease.Signal transduction and targeted therapy · 2020Review
- Review
- Fibroblast Growth Factor Receptors Function Redundantly During Zebrafish Embryonic Development.Genetics · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
The neurocranium generates most of the craniofacial skeleton and consists of prechordal and postchordal regions. Although development of the prechordal is well studied, little is known of the postchordal region. Here we characterize a signaling hierarchy necessary for postchordal neurocranial development involving Fibroblast growth factor (Fgf) signaling for early specification of mesodermally-derived progenitor cells. The expression of hyaluron synthetase 2 (has2) in the cephalic mesoderm requires Fgf signaling and Has2 function, in turn, is required for postchordal neurocranial development. While Hedgehog (Hh)-deficient embryos also lack a postchordal neurocranium, this appears primarily due to a later defect in chondrocyte differentiation. Inhibitor studies demonstrate that postchordal neurocranial development requires early Fgf and later Hh signaling. Collectively, our results provide a mechanistic understanding of early postchordal neurocranial development and demonstrate a hierarchy of signaling between Fgf and Hh in the development of this structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.