ArticleBiochimica et biophysica acta2016
Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation.
Article in Biochimica et biophysica acta, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Culture medium modulates nucleolar architecture and disrupts ribosomal RNA levels in preimplantation mouse embryos.The Journal of reproduction and development · 2026Article
- Embryonic Mediators of Embryo-Uterus Communication, Implantation and Pregnancy.Molecular reproduction and development · 2026Review
- Maternal Undernutrition Induces Cell Signalling and Metabolic Dysfunction in Undifferentiated Mouse Embryonic Stem Cells.Stem cell reviews and reports · 2023Article
- The influence of early environment and micronutrient availability on developmental epigenetic programming: lessons from the placenta.Frontiers in cell and developmental biology · 2023Review
- Genetic variation at mouse and human ribosomal DNA influences associated epigenetic states.Genome biology · 2022Article
- Review
- Environmental Exposures around Conception: Developmental Pathways Leading to Lifetime Disease Risk.International journal of environmental research and public health · 2021Review
- Single cell epigenetic visualization assay.Nucleic acids research · 2021Article
- Sex-specific epigenetic profile of inner cell mass of mice conceived in vivo or by IVF.Molecular human reproduction · 2020Article
- Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver.Nutrients · 2020Article
- RW-2018-Research Workshop: The Effect of Nutrition on Epigenetic Status, Growth, and Health.JPEN. Journal of parenteral and enteral nutrition · 2019Review
- Review
- Maternal and environmental risk factors for neonatal AKI and its long-term consequences.Nature reviews. Nephrology · 2018Review
- Chaperones, Canalization, and Evolution of Animal Forms.International journal of molecular sciences · 2018Review
- Mouse maternal protein restriction during preimplantation alone permanently alters brain neuron proportion and adult short-term memory.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- When maternal periconceptional diet affects neurological development, it's time to think.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
- Origins of lifetime health around the time of conception: causes and consequences.Lancet (London, England) · 2018Review
- Early life diet conditions the molecular response to post-weaning protein restriction in the mouse.BMC biology · 2018Article
- Parental micronutrient deficiency distorts liver DNA methylation and expression of lipid genes associated with a fatty-liver-like phenotype in offspring.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Cells and organisms respond to nutrient deprivation by decreasing global rates of transcription, translation and DNA replication. To what extent such changes can be reversed is largely unknown. We examined the effect of maternal dietary restriction on RNA synthesis in the offspring. Low protein diet fed either throughout gestation or for the preimplantation period alone reduced cellular RNA content across fetal somatic tissues during challenge and increased it beyond controls in fetal and adult tissues after challenge release. Changes in transcription of ribosomal RNA, the major component of cellular RNA, were responsible for this phenotype as evidenced by matching alterations in RNA polymerase I density and DNA methylation at ribosomal DNA loci. Cellular levels of the ribosomal transcription factor Rrn3 mirrored the rRNA expression pattern. In cell culture experiments, Rrn3 overexpression reduced rDNA methylation and increased rRNA expression; the converse occurred after inhibition of Rrn3 activity. These observations define novel mechanism where poor nutrition before implantation irreversibly alters basal rates of rRNA transcription thereafter in a process mediated by rDNA methylation and Rrn3 factor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.