Evidence map›Paper›PMID 27060384›Full record

ArticleJournal of neuroscience methods2016

Second spatial derivative analysis of cortical surface potentials recorded in cat primary auditory cortex using thin film surface arrays: Comparisons with multi-unit data.

James B Fallon, Sam Irving, Satinderpall S Pannu, Angela C Tooker, Andrew K Wise, Robert K Shepherd, Dexter R F Irvine

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

James B FallonBionics Institute, Melbourne, Victoria, Australia; Department of Otolaryngology, University of Melbourne, Melbourne, Victoria, Australia; Medical Bionics Department, University of Melbourne, Melbourne, Victoria, Australia. Electronic address: jfallon@bionicsinstitute.org.
Sam IrvingBionics Institute, Melbourne, Victoria, Australia.
Satinderpall S PannuLawrence Livermore National Laboratory, Livermore, CA, United States.
Angela C TookerLawrence Livermore National Laboratory, Livermore, CA, United States.
Andrew K WiseBionics Institute, Melbourne, Victoria, Australia; Department of Otolaryngology, University of Melbourne, Melbourne, Victoria, Australia; Medical Bionics Department, University of Melbourne, Melbourne, Victoria, Australia.
Robert K ShepherdBionics Institute, Melbourne, Victoria, Australia; Medical Bionics Department, University of Melbourne, Melbourne, Victoria, Australia.
Dexter R F IrvineBionics Institute, Melbourne, Victoria, Australia.

Funding

NIDCD NIH HHS Y01 DC008002
6 · The paper itself

Abstract

backgroundCurrent source density analysis of recordings from penetrating electrode arrays has traditionally been used to examine the layer- specific cortical activation and plastic changes associated with changed afferent input. We report on a related analysis, the second spatial derivative (SSD) of surface local field potentials (LFPs) recorded using custom designed thin-film polyimide substrate arrays.

resultsSSD analysis of tone- evoked LFPs generated from the auditory cortex under the recording array demonstrated a stereotypical single local minimum, often flanked by maxima on both the caudal and rostral sides. In contrast, tone-pips at frequencies not represented in the region under the array, but known (on the basis of normal tonotopic organization) to be represented caudal to the recording array, had a more complex pattern of many sources and sinks. COMPARISON WITH EXISTING

methodsCompared to traditional analysis of LFPs, SSD analysis produced a tonotopic map that was more similar to that obtained with multi-unit recordings in a normal-hearing animal. Additionally, the statistically significant decrease in the number of acoustically responsive cortical locations in partially deafened cats following 6 months of cochlear implant use compared to unstimulated cases observed with multi-unit data (p=0.04) was also observed with SSD analysis (p=0.02), but was not apparent using traditional analysis of LFPs (p=0.6).

conclusionsSSD analysis of surface LFPs from the thin-film array provides a rapid and robust method for examining the spatial distribution of cortical activity with improved spatial resolution compared to more traditional LFP recordings.

Indexed as

Electrodes, ImplantedSignal Processing, Computer-AssistedAcoustic StimulationAnimalsAuditory CortexAuditory PerceptionCatsCochlear ImplantsDeafnessDisease Models, AnimalEquipment DesignEvoked Potentials, AuditoryKanamycinKanamycinCochlear implantCortical plasticityLocal field potentialNeural prosthesisSensorineural hearing loss

Identifiers

PMID27060384
PMCPMC4884480

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.