ArticlePediatric nephrology (Berlin, Germany)2016
Pediatric combined liver-kidney transplantation: a single-center experience of 18 cases.
Article in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Transplantation outcomes in patients with primary hyperoxaluria: a systematic review.Pediatric nephrology (Berlin, Germany) · 2021Pooled it
- Guidelines for the diagnosis and management of methylmalonic acidaemia and propionic acidaemia: First revision.Journal of inherited metabolic disease · 2021Guideline
- Hyperoxaluria: Diagnosis and Treatment.The Urologic clinics of North America · 2025Review
- Real-Life Data of 2-Year Lumasiran Use in the DAILY-LUMA Cohort.Kidney international reports · 2025Article
- Native nephrectomy in advanced pediatric kidney disease: indications, timing, and surgical approaches.Pediatric nephrology (Berlin, Germany) · 2024Review
- Genotype and phenotype analysis and transplantation strategy in children with kidney failure caused by NPHP.Pediatric nephrology (Berlin, Germany) · 2023Article
- Clinical practice recommendations for primary hyperoxaluria: an expert consensus statement from ERKNet and OxalEurope.Nature reviews. Nephrology · 2023Review
- Effect of liver transplantation with primary hyperoxaluria type 1: Five case reports and review of literature.World journal of clinical cases · 2023Article
- Long-term outcome after combined or sequential liver and kidney transplantation in children with infantile and juvenile primary hyperoxaluria type 1.Frontiers in pediatrics · 2023Article
- Long-Term Transplantation Outcomes in Patients With Primary Hyperoxaluria Type 1 Included in the European Hyperoxaluria Consortium (OxalEurope) Registry.Kidney international reports · 2022Article
- The Struggling Odyssey of Infantile Primary Hyperoxaluria.Frontiers in pediatrics · 2021Article
- Case Report: Homozygous Pathogenic Variant P209L in theFrontiers in medicine · 2021Article
- Combined liver-kidney transplantation for rare diseases.World journal of hepatology · 2020Review
- Deceased vs living donor grafts for pediatric simultaneous liver-kidney transplantation: A single-center experience.Journal of clinical laboratory analysis · 2020Article
- Post-transplantation Outcomes in Patients with PA or MMA: A Review of the Literature.Advances in therapy · 2020Review
- Skin microvascular dysfunction as an early cardiovascular marker in primary hyperoxaluria type I.Pediatric nephrology (Berlin, Germany) · 2019Article
- Combined and sequential liver-kidney transplantation in children.Pediatric nephrology (Berlin, Germany) · 2018Review
- Bilateral native nephrectomy to reduce oxalate stores in children at the time of combined liver-kidney transplantation for primary hyperoxaluria type 1.Pediatric nephrology (Berlin, Germany) · 2018Article
- Long-term successful liver-kidney transplantation in a child with atypical hemolytic uremic syndrome caused by homozygous factor H deficiency.Pediatric nephrology (Berlin, Germany) · 2016Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExperience in combined liver-kidney transplantation (CLKT) in children is limited.
methodsWe conducted a retrospective study of all pediatric CLKTs performed at our medical institution between 1992 and 2013.
resultsWe identified 18 pediatric patients (9 girls) who had undergone CLKT at our institution during the study period. The median age [range] and body weight [range] of this patient group was 3.6 [1.0-18.6] years and 13 [10-40] kg, respectively; 11 patients weighed <15 kg at the time of CLKT. Indications for CLKT were primary hyperoxaluria (PH1; n = 14), association of hepatic fibrosis and end-stage renal disease (n = 3) and methylmalonic acidemia (n = 1). In the early postoperative period, eight patients required dialysis. Median stay in the pediatric intensive care unit was 10 [6-29] days. One patient died from cardiovascular disease 10 years after CLKT. There were no liver graft losses despite six acute liver rejection episodes, whereas four kidney grafts were lost. At last follow-up (6 [0.5-21] years) for patients with a functioning renal graft, the glomerular filtration rate was 71 [26-146] mL/min/1.73 m(2). In PH1 patients, urine oxalate normalized in six patients within 3 years after CLKT, but three patients still presented with elevated oxaluria at 1, 2 and 3 years after CLKT.
conclusionsPediatric CLKT provides encouraging results in the long term, even in the youngest patients.
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