Evidence map›Paper›PMID 27059883›Full record

ReviewDevelopmental biology2016

White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies.

Alan J Burns, Allan M Goldstein, Donald F Newgreen, Lincon Stamp, Karl-Herbert Schäfer, Marco Metzger, Ryo Hotta, Heather M Young, Peter W Andrews, Nikhil Thapar and 20 more

Open access · hybridAbstract readReviewConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Review in Developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 146 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Unlocking the Neurogenic Potential of Enteric Glial Cells for Hirschsprung Disease Therapy.Cellular and molecular gastroenterology and hepatology · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Surgical pathology of Hirschsprung disease (HSCR).World journal of pediatric surgery · 2025
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 20 institutions in 10 countries.

Alan J BurnsStem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: alan.burns@ucl.ac.uk.
Allan M GoldsteinDepartment of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Donald F NewgreenMurdoch Childrens Research Institute, Royal Children's Hospital, Parkville 3052, Victoria, Australia.
Lincon StampDepartment of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia.
Karl-Herbert SchäferUniversity of Applied Sciences, Kaiserlautern, Germany; Clinic of Pediatric Surgery, University Hospital Mannheim, University Heidelberg, Germany.
Marco MetzgerFraunhofer-Institute Interfacial Engineering and Biotechnology IGB Translational Centre - Würzburg branch and University Hospital Würzburg - Tissue Engineering and Regenerative Medicine (TERM), Würzburg, Germany.
Ryo HottaDepartment of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Heather M YoungDepartment of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia.
Peter W AndrewsCentre for Stem Cell Biology, Department of Biomedical Science, University of Sheffield, Sheffield, UK.
Nikhil ThaparStem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, London, UK.
Jaime Belkind-GersonDivision of Gastroenterology, Hepatology and Nutrition, Massachusetts General Hospital for Children, Harvard Medical School, Boston, USA.
Nadege BondurandINSERM U955, 51 Avenue du Maréchal de Lattre de Tassigny, F-94000 Créteil, France; Université Paris-Est, UPEC, F-94000 Créteil, France.
Joel C BornsteinDepartment of Physiology, University of Melbourne, Parkville, Victoria 3010, Australia.
Wood Yee ChanSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
Kathryn CheahSchool of Biomedical Sciences, The University of Hong Kong, Hong Kong.
Michael D GershonDepartment of Pathology and Cell Biology, Columbia University, New York 10032, USA.
Robert O HeuckerothDepartment of Pediatrics, The Children's Hospital of Philadelphia Research Institute, Philadelphia, PA 19104, USA; Perelman School of Medicine at the University of Pennsylvania, Abramson Research Center, Philadelphia, PA 19104, USA.
Robert M W HofstraStem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.
Lothar JustInstitute of Clinical Anatomy and Cell Analysis, University of Tübingen, Germany.
Raj P KapurDepartment of Pathology, University of Washington and Seattle Children's Hospital, Seattle, WA, USA.
Sebastian K KingDepartment of Paediatric and Neonatal Surgery, The Royal Children's Hospital, Melbourne, Australia.
Conor J McCannStem Cells and Regenerative Medicine, UCL Great Ormond Street Institute of Child Health, London, UK.
Nandor NagyDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
Elly NganDepartment of Surgery, The University of Hong Kong, Hong Kong.
Florian ObermayrDepartment of Pediatric Surgery and Pediatric Urology, University Children's Hospital Tübingen, D-72076 Tübingen, Germany.
Vassilis PachnisThe Francis Crick Institute, Mill Hill Laboratory, London, UK.
Pankaj J PasrichaJohns Hopkins Center for Neurogastroenterology, Baltimore, MD, USA.
Mai Har ShamDepartment of Biochemistry, The University of Hong Kong, Hong Kong.
Paul TamDepartment of Surgery, The University of Hong Kong, Hong Kong.
Pieter Vanden BergheLaboratory for Enteric NeuroScience (LENS), TARGID, University of Leuven, Belgium.
University of Melbourne · AUUniversity of Hong Kong · HKGreat Ormond Street Hospital · GBMassachusetts General Hospital · USUniversity College London · GBUniversity of Sheffield · GBChildren's Hospital of Philadelphia · USChinese University of Hong Kong · CNColumbia University · USHarvard University · USHeidelberg University · DEInserm · FRKU Leuven · BEMurdoch Children's Research Institute · AURoyal Children's Hospital · AUSemmelweis University · HUUniversitätsklinikum Würzburg · DEUniversity Children's Hospital Tübingen · DEUniversity of Tübingen · DEUniversity of Washington · US

Funding

MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENTR01NS015547 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GERSHON, MICHAEL D, MARGOLIS, KARA GROSS · 1985 to 2022
$7.2M
Genes, Environment & Neural Stem Cell Transplantation in the GutR01DK080920 · NIDDK · STANFORD UNIVERSITY · PI PASRICHA, PANKAJ J · 2009 to 2017
$2.9M
Developmentally Informed Approach to Cell-based Therapy for Enteric NeuropathiesR01DK103785 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI GOLDSTEIN, ALLAN M · 2015 to 2019
$1.9M
Medical Research Council G0800973Medical Research Council MR/L012537/1NIDDK NIH HHS R01 DK080920NIDDK NIH HHS R01 DK103785NINDS NIH HHS R01 NS015547
6 · The paper itself

Abstract

Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts' views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.

Indexed as

Stem Cell TransplantationAnimalsCell- and Tissue-Based TherapyDisease Models, AnimalEnteric Nervous SystemGastrointestinal TractGuidelines as TopicHirschsprung DiseaseHumansIntestinal Pseudo-ObstructionNeural Stem CellsCell replacement therapyEnteric nervous systemEnteric neuropathiesHirschsprung diseaseStem cells

Identifiers

PMID27059883
PMCPMC5026875
OpenAlexW2320275480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.