ReviewWorld journal of pediatrics : WJP2016
Diagnosis and management of pediatric adrenal insufficiency.
Review in World journal of pediatrics : WJP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Adverse Events Associated with Clascoterone: A Real-World Pharmacovigilance Study of the Food and Drug Administration Adverse Event Reporting System.Therapeutic innovation & regulatory science · 2026Article
- Clinical and genetic insights into congenital lipoid adrenal hyperplasia: a case series from a tertiary care center in North India.Journal of pediatric endocrinology & metabolism : JPEM · 2025Article
- Interpretation of Neonatal Adrenal Function Results and Adrenal Function Results in Critical IllnessJournal of clinical research in pediatric endocrinology · 2025Review
- A Rare Presentation of Homozygous Pathogenic Variant inMolecular syndromology · 2024Article
- Thyroid dysfunction in infants with severe intestinal insufficiency: a case series.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2023Article
- [Emergency card, emergency medication, and information leaflet for the prevention and treatment of adrenal crisis (Addison crisis): an Austrian consensus document].Journal fur klinische Endokrinologie und Stoffwechsel · 2022Article
- Type 1 Diabetes and Addison's Disease: When the Diagnosis Is Suggested by the Continuous Glucose Monitoring System.Children (Basel, Switzerland) · 2021Article
- Revisiting peak serum cortisol response to insulin-induced hypoglycemia in children.Journal of endocrinological investigation · 2021Article
- Pediatric Primary Adrenal Insufficiency: A 21-year Single Center ExperienceJournal of clinical research in pediatric endocrinology · 2021Article
- Evolving pituitary hormone deficits in primarily isolated GHD: a review and experts' consensus.Molecular and cellular pediatrics · 2020Review
- Case 1-2020: An 11-Year-Old Boy with Vomiting and Weight Loss.The New England journal of medicine · 2020Article
- Salivary biomarkers may measure stress responses in critically ill children.SAGE open medicine · 2018Article
- A novel splice site variant in CYP11A1 in trans with the p.E314K variant in a male patient with congenital adrenal insufficiency.Molecular genetics & genomic medicine · 2017Article
- Fatal Rotavirus Infection in a 4-Year-Old with Unsuspected Autoimmune Adrenal Insufficiency.Academic forensic pathology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdrenal insufficiency (AI) is a wellknown cause of potentially life-threatening disorders. Defects at each level of the hypothalamic-pituitary-adrenal axis can impair adrenal function, leading to varying degrees of glucocorticoid (GC) deficiency. Iatrogenic AI induced by exogenous GCs is the most common cause of AI. The criteria for the diagnosis and management of iatrogenic AI, neonatal AI, and critical illness-related corticosteroid insufficiency (CIRCI) are not clear. DATA SOURCES: We reviewed the recent original publications and classical data from the literature, as well as the clinical, diagnostic and management strategies of pediatric AI.
resultsPractical points in the diagnosis and management of AI with an emphasis on iatrogenic AI, neonatal AI, and CIRCI are provided. Given the lack of sensitive and practical biochemical tests for diagnosis of subtle AI, GC treatment has to be tailored to highly suggestive clinical symptoms and signs. Treatment of adrenal crisis is well standardized and patients almost invariably respond well to therapy. It is mainly the delay in treatment that is responsible for mortality in adrenal crisis.
conclusionsEducation of patients and health care professionals is mandatory for timely interventions for patients with adrenal crisis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.