ArticleWorld journal of pediatrics : WJP2016
Probiotics prophylaxis in pyelonephritis infants with normal urinary tracts.
Article in World journal of pediatrics : WJP, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Efficacy of Probiotic Supplementation for Preventing Pediatric Urinary Tract Infections: A GRADE-Based Dose-Response Meta-Analysis.Health science reports · 2026Review
- Unlocking the probiotic potential of breast milk-derived lactobacillus against urinary tract infections: mechanisms, therapeutic prospects, and future directions.Antonie van Leeuwenhoek · 2026Review
- Effect of probiotics and synbiotics on antimicrobial resistance in frequent infections: a systematic review of clinical trials.Annals of medicine and surgery (2012) · 2026Article
- Article
- Intestinal Microbiota Correction in the Treatment and Prevention of Urinary Tract Infection.Turkish journal of urology · 2022Article
- Non-antibiotic Approaches to Preventing Pediatric UTIs: a Role for D-Mannose, Cranberry, and Probiotics?Current urology reports · 2022Review
- Examination of Complementary Medicine for Treating Urinary Tract Infections Among Pregnant Women and Children.Frontiers in pharmacology · 2022Review
- Article
- [Is there still no alternative to long-term antibacterial prophylaxis?]Der Urologe. Ausg. A · 2020Review
- Update on Associated Risk Factors, Diagnosis, and Management of Recurrent Urinary Tract Infections in Children.Journal of the Pediatric Infectious Diseases Society · 2019Review
- Urinary Tract Infection in Children.Recent patents on inflammation & allergy drug discovery · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPyelonephritis in infants is considered as a major factor for the formation of renal scar. To prevent recurrent pyelonephritis and renal damage, prophylaxis is extremely important. The aim of this study was to compare the effectiveness of probiotic and antibiotic prophylaxis or no-prophylaxis in infants with pyelonephritis and normal urinary tract.
methodsAltogether 191 infants, who were diagnosed with acute pyelonephritis, proven to have normal urinary tracts and followed up for 6 months on prophylaxis, were retrospectively evaluated. According to the types of prophylaxis, the infants were divided into three groups [probiotics (Lactobacillus species), antibiotics (trimethoprim/sulfamethoxazole, TMP/SMX), and noprophylaxis]. The incidence of recurrent urinary tract infection (UTI) during 6 months after the development of pyelonephritis, main causative uropathogens, and its antimicrobial sensitivities were compared.
resultsThe incidence of recurrent UTI in the probiotic group was 8.2%, which was significantly lower than 20.6% in the no-prophylaxis group (P=0.035) and was not significantly different from 10.0% of the antibiotic group (P=0.532). The significant difference between the probiotic and no-prophylaxis groups was seen only in male infants (P=0.032). The main causative organism of recurrent UTI was Escherichia coli (E.coli), which was not different among the three groups (P=0.305). The resistance rate of E. coli to TMP/SMX was 100% in the antibiotic group, which was significantly higher than 25.0% in the probiotic group and 41.7% in the no-prophylaxis group (P=0.008).
conclusionProbiotic prophylaxis was more effective in infants with pyelonephritis and normal urinary tract than in those with no-prophylaxis. It could be used as a natural alternative to antibiotic prophylaxis.
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