Evidence map›Paper›PMID 27059719›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2016

Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation.

Siva Kumar Solleti, Sorachai Srisuma, Soumyaroop Bhattacharya, Javier Rangel-Moreno, Kaiser M Bijli, Troy D Randall, Arshad Rahman, Thomas J Mariani

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Twenty years of changes in the definition of early chronic obstructive pulmonary disease.Chinese medical journal pulmonary and critical care medicine · 2023
    Review
  4. Article
  5. Review
  6. Biotite-Calx Based Traditional Indian MedicineJournal of inflammation research · 2021
    Article
  7. Role of iBALT in Respiratory Immunity.Current topics in microbiology and immunology · 2020
    Review
  8. Article
  9. Review
  10. The etiologic origins for chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2019
    Review
  11. Article
  12. Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018
    Article
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Siva Kumar SolletiDivision of Neonatology, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA;
Sorachai SrisumaDepartment of Physiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand;
Soumyaroop BhattacharyaDivision of Neonatology, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA;
Javier Rangel-MorenoDivision of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, New York, USA;
Kaiser M BijliDivision of Neonatology, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA; Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University/Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, USA;
Troy D RandallDivision of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, New York, USA; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Arshad RahmanDivision of Neonatology, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA;
Thomas J MarianiDivision of Neonatology, Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA; tom_mariani@urmc.rochester.edu.
University of Rochester Medical Center · USAtlanta VA Medical Center · USMahidol University · THUniversity of Alabama at Birmingham · US

Funding

PPAR gamma as a therapeutic target in COPDR01HL094431 · NHLBI · UNIVERSITY OF ROCHESTER · PI MARIANI, THOMAS J · 2011 to 2014
$1.5M
Regulation of Lung Authopagy and InflammationR01HL116632 · NHLBI · UNIVERSITY OF ROCHESTER · PI RAHMAN, ARSHAD · 2013 to 2016
$1.5M
SERPINE2 as a Candidate COPD Susceptibility GeneR21ES014372 · NIEHS · UNIVERSITY OF ROCHESTER · PI MARIANI, THOMAS J · 2007 to 2008
$318k
NHLBI NIH HHS R01 HL094431NHLBI NIH HHS R01 HL116632NIEHS NIH HHS R21 ES014372
6 · The paper itself

Abstract

Serine proteinase inhibitor, clade E, member 2 (SERPINE2), is a cell- and extracellular matrix-associated inhibitor of thrombin. Although SERPINE2 is a candidate susceptibility gene for chronic obstructive pulmonary disease, the physiologic role of this protease inhibitor in lung development and homeostasis is unknown. We observed spontaneous monocytic-cell infiltration in the lungs of Serpine2-deficient (SE2(-/-)) mice, beginning at or before the time of lung maturity, which resulted in lesions that resembled bronchus-associated lymphoid tissue (BALT). The initiation of lymphocyte accumulation in the lungs of SE2(-/-) mice involved the excessive expression of chemokines, cytokines, and adhesion molecules that are essential for BALT induction, organization, and maintenance. BALT-like lesion formation in the lungs of SE2(-/-) mice was also associated with a significant increase in the activation of thrombin, a recognized target of SE2, and excess stimulation of NF-κB, a major regulator of chemokine expression and inflammation. Finally, systemic delivery of thrombin rapidly stimulated lung chemokine expression in vivo These data uncover a novel mechanism whereby loss of serine protease inhibition leads to lung lymphocyte accumulation.-Solleti, S. K., Srisuma, S., Bhattacharya, S., Rangel-Moreno, J., Bijli, K. M., Randall, T. D., Rahman, A., Mariani, T. J. Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation.

Indexed as

AnimalsBronchiGene Expression RegulationLungLymphocytesLymphoid TissueMiceMice, KnockoutSerpin E2Serpin E2Serpine2 protein, mousechemokinesprotease nexin-1serine protease inhibitortertiary lymphoid structuresthrombin

Identifiers

PMID27059719
PMCPMC6137455
OpenAlexW2335516022

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.