ReviewJournal of the Pediatric Infectious Diseases Society2016
Challenges in the Etiology and Diagnosis of Acute Febrile Illness in Children in Low- and Middle-Income Countries.
Review in Journal of the Pediatric Infectious Diseases Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06122259 (Multidisciplinary Surveillance and Investigation of Febrile Illness in Guinea), which is not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multidisciplinary Surveillance and Investigation of Febrile Illness in Guinea
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Cost-effectiveness of point-of-care diagnostics for AMR: a systematic review.The Journal of antimicrobial chemotherapy · 2024Pooled it
- A systematic review and meta-analysis of the aetiological agents of non-malarial febrile illnesses in Africa.PLoS neglected tropical diseases · 2022Pooled it
- Impact of the Introduction of a Package of Diagnostic Tools, Diagnostic Algorithm, and Training and Communication on Outpatient Acute Fever Case Management at 3 Diverse Sites in Uganda: Results of a Randomized Controlled Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Trial
- Seroprevalence of Rift Valley fever virus and factors associated with exposure in south-central Uganda.BMC infectious diseases · 2026Article
- A 13-year cohort study using clinical machine learning to differentiate bacterial and viral infections in young infants in a dengue hyperendemic region.Journal of tropical pediatrics · 2026Article
- Saliva, urine, and anorectal swabs as viable alternatives to lesion swabs for molecular diagnosis of mpox.Nature communications · 2026Article
- Identifying the motivators, benefits and barriers to sharing participant-level data and samples: results from an international online survey of acute febrile illness cohort teams.BMC medical ethics · 2026Article
- Clinical profile and predictors of adverse outcomes in pediatric dengue fever presenting with febrile illness: a prospective observational study in Burao, Somaliland.Frontiers in pediatrics · 2026Article
- Geospatial Mapping of Pediatric Febrile Illness in Uganda to Inform Precision Public Health Interventions.Open forum infectious diseases · 2026Article
- Clinical Profile, Syndromic Classification, and Studying the Seasonal Variation and Geo-mapping of the Patients with Febrile Illness Reporting to a Primary Health Center in Puducherry.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2025Article
- Epidemiology and Outcomes of Pediatric Fever in a Rural District of Southern Mozambique: 17 Years of Morbidity Surveillance.Open forum infectious diseases · 2025Article
- Syndromic presentation by patients with malaria and respiratory symptoms in a malaria-endemic urban-and-peri-urban setting.BMC research notes · 2025Article
- Heterologous Expression, Purification, and Characterization of a High-Temperature Requirement A (HtrA) Protease Homologue from Leptospira.Applied biochemistry and biotechnology · 2025Article
- Optimizing pediatric emergency triage in low-resource settings: evidence-based strategies, task-shifting, and technological innovations.International journal of emergency medicine · 2025Review
- Detection of pathogens associated with acute febrile illness in children under five years of age in rural Tanzania.Scientific reports · 2025Article
- Clinical and epidemiological characteristics of influenza and SARS-CoV-2 virus among patients with acute febrile illness in selected sites of Ethiopia 2021-2022.Frontiers in public health · 2025Article
- Respiratory syncytial virus vaccines for toddlers and school-aged children: a pressing necessity for global health.Frontiers in pediatrics · 2025Article
- Re-emergence of Oropouche virus as a novel global threat.Current research in microbial sciences · 2025Review
- Demographic and Clinical Factors Associated with Bacterial or Nonbacterial Etiologies of Acute Undifferentiated Febrile Illness: Findings from a 3-Year Observational Study in Thailand, 2017-2020.The American journal of tropical medicine and hygiene · 2024Observational
- Understanding the Transmission Dynamics of the Chikungunya Virus in Africa.Pathogens (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute febrile illness is a common cause of hospital admission, and its associated infectious causes contribute to substantial morbidity and death among children worldwide, especially in low- and middle-income countries. Declining transmission of malaria in many regions, combined with the increasing use of rapid diagnostic tests for malaria, has led to the increasing recognition of leptospirosis, rickettsioses, respiratory viruses, and arboviruses as etiologic agents of fevers. However, clinical discrimination between these etiologies can be difficult. Overtreatment with antimalarial drugs is common, even in the setting of a negative test result, as is overtreatment with empiric antibacterial drugs. Viral etiologies remain underrecognized and poorly investigated. More-sensitive diagnostics have led to additional dilemmas in discriminating whether a positive test result reflects a causative pathogen. Here, we review and summarize the current epidemiology and focus particularly on children and the challenges for future research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.