Evidence map›Paper›PMID 27059500›Full record

ArticleAnnals of intensive care2016

Association of REL polymorphisms and outcome of patients with septic shock.

Julie Toubiana, Emilie Courtine, Frederic Tores, Pierre Asfar, Cédric Daubin, Christophe Rousseau, Fatah Ouaaz, Nathalie Marin, Alain Cariou, Jean-Daniel Chiche and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of intensive care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Julie ToubianaMedical School, Paris Descartes University, Paris, France. julie.toubiana@aphp.fr.
Emilie CourtineMedical School, Paris Descartes University, Paris, France.
Frederic ToresBioinformatics Platform, Institut Imagine, Paris Descartes University- Sorbonne Paris Cité, 75015, Paris, France.
Pierre AsfarMedical Intensive Care Unit, Angers University Hospital, Angers, France.
Cédric DaubinMedical Intensive Care, Caen University Hospital, Caen, France.
Christophe RousseauINSERM U1016, CNRS UMR 8104, Cochin Institute, Paris, France.
Fatah OuaazINSERM U1016, CNRS UMR 8104, Cochin Institute, Paris, France.
Nathalie MarinIntensive Care Unit, Cochin University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France.
Alain CariouMedical School, Paris Descartes University, Paris, France.
Jean-Daniel ChicheMedical School, Paris Descartes University, Paris, France.
Jean-Paul MiraMedical School, Paris Descartes University, Paris, France.
Inserm · FRCentre National de la Recherche Scientifique · FRUniversité Paris Cité · FRAssistance Publique – Hôpitaux de Paris · FRDélégation Paris 5 · FRUniversité d'Angers · FRUniversité de Caen Normandie · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundcRel, a subunit of NF-κB, is implicated in the inflammatory response observed in autoimmune disease. Hence, knocked-out mice for cRel had a significantly higher mortality, providing new and important functions of cRel in the physiopathology of septic shock. Whether genetic variants in the human REL gene are associated with severity of septic shock is unknown.

methodsWe genotyped a population of 1040 ICU patients with septic shock and 855 ICU controls for two known polymorphisms of REL; REL rs842647 and REL rs13031237. Outcome of patients according to the presence of REL variant alleles was compared.

resultsThe distribution of REL variant alleles was not significantly different between patients and controls. Among the septic shock group, REL rs13031237*T minor allele was not associated with worse outcome. In contrast, REL rs842647*G minor allele was significantly associated with more multi-organ failure and early death [OR 1.4; 95 % CI (1.02-1.8)].

conclusionIn a large ICU population, we report a significant clinical association between a variation in the human REL gene and severity and mortality of septic shock, suggesting for the first time a new insight into the role of cRel in response to infection in humans.

Indexed as

cRelGeneticsMortalityMulti-organ dysfunction syndromePolymorphismRELSeptic shock

Identifiers

PMID27059500
PMCPMC4826362
OpenAlexW2319692471

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.