Evidence map›Paper›PMID 27059469›Full record

Trial reportBMJ open2016

CYCLE pilot: a protocol for a pilot randomised study of early cycle ergometry versus routine physiotherapy in mechanically ventilated patients.

Michelle E Kho, Alexander J Molloy, France Clarke, Margaret S Herridge, Karen K Y Koo, Jill Rudkowski, Andrew J E Seely, Joseph R Pellizzari, Jean-Eric Tarride, Marina Mourtzakis and 3 more

2 registry-linked trialsAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02377830 phase2completednot on this map

CYCLE Pilot: A Pilot Randomized Study of Early Cycle Ergometry Versus Routine Physiotherapy in Mechanically Ventilated Patients

TypeinterventionalSponsorMcMaster UniversityRan2015 to 2018Enrolled113ConditionsIntensive Care Unit Acquired Weakness, Critical Care, Mechanical Ventilation, Respiratory FailureArmsIn-bed cycle ergometer (Restorative Therapies RT300 Supine), Routine physiotherapy
NCT07017517 narecruitingnot on this mapstarted 2026, after this paper: background citation

Effect of Physical Therapy on NLRP3 Inflammasome Activation and Muscle Atrophy in Critical Illness Myopathy (PT-NLRP3-CIM).

TypeinterventionalSponsorUniversity of ChileRan2026 to 2027Enrolled24ConditionsCritical Illness MyopathyArmsMotomed Letto® servo-assisted cycling + standard physiotherapy, Standard physiotherapy
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michelle E KhoMcMaster University, School of Rehabilitation Science, Hamilton, Ontario, Canada Department of Physiotherapy, St. Joseph's Healthcare, Hamilton, Ontario, Canada Department of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, Maryland, USA.ORCID http://orcid.org/0000-0003-3170-031X
Alexander J MolloyDepartment of Physiotherapy, St. Joseph's Healthcare, Hamilton, Ontario, Canada.
France ClarkeDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada.
Margaret S HerridgeDepartment of Medicine, University of Toronto, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
Karen K Y KooSwedish Early Mobility Program in Critical Care, Swedish Medical Group, First Hill Campus, Seattle, Washington, USA Department of Medicine, Western University, London, Ontario, Canada.
Jill RudkowskiDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Andrew J E SeelyOttawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
Joseph R PellizzariConsultation-Liaison Psychiatry Service, St. Joseph's Healthcare, Hamilton, Ontario, Canada Department of Psychiatry and Behavioural Neurosciences, McMaster University, Ontario, Canada.
Jean-Eric TarrideDepartment of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada Programs for the Assessment of Technology in Health, Research Institute of St. Joe's Hamilton, Hamilton, Ontario, Canada.
Marina MourtzakisDepartment of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.
Timothy KarachiDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Deborah J CookDepartment of Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, Maryland, USA Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Canadian Critical Care Trials Group

Funding

Molecular Basis of Berberine-Mediated Antitumor ActivityF05AT002014 · NCCIH · UNIVERSITY OF CHICAGO · PI KANG, QUAN · 2003 to 2007
$183k
Canadian Institutes of Health Research 142327NCCIH NIH HHS F05 AT002014
6 · The paper itself

Abstract

introductionEarly exercise with in-bed cycling as part of an intensive care unit (ICU) rehabilitation programme has the potential to improve physical and functional outcomes following critical illness. The objective of this study is to determine the feasibility of enrolling adults in a multicentre pilot randomised clinical trial (RCT) of early in-bed cycling versus routine physiotherapy to inform a larger RCT. METHODS AND ANALYSIS: 60-patient parallel group pilot RCT in 7 Canadian medical-surgical ICUs. We will include all previously ambulatory adult patients within the first 0-4 days of mechanical ventilation, without exclusion criteria. After informed consent, patients will be randomised using a web-based, centralised electronic system, to 30 min of in-bed leg cycling in addition to routine physiotherapy, 5 days per week, for the duration of their ICU stay (28 days maximum) or routine physiotherapy alone. We will measure patients' muscle strength (Medical Research Council Sum Score, quadriceps force) and function (Physical Function in ICU Test (scored), 30 s sit-to-stand, 2 min walk test) at ICU awakening, ICU discharge and hospital discharge. Our 4 feasibility outcomes are: (1) patient accrual of 1-2 patients per month per centre, (2) protocol violation rate <20%, (3) outcome measure ascertainment >80% at the 3 time points and (4) blinded outcomes ascertainment >80% at hospital discharge. Hospital outcome assessors are blinded to group assignment, whereas participants, ICU physiotherapists, ICU caregivers, research coordinators and ICU outcome assessors are not blinded to group assignment. We will analyse feasibility outcomes with descriptive statistics. ETHICS AND DISSEMINATION: Each participating centre will obtain local ethics approval, and results of the study will be published to inform the design and conduct of a future multicentre RCT of in-bed cycling to improve physical outcomes in ICU survivors. TRIAL REGISTRATION NUMBER: NCT02377830; Pre-results.

Indexed as

ExerciseIntensive Care UnitsRespiration, ArtificialAdultBedsCanadaClinical ProtocolsCritical IllnessExercise TherapyFeasibility StudiesHospitalizationHumansMuscle StrengthPhysical Therapy ModalitiesPilot ProjectsQuadriceps MuscleSTATISTICS & RESEARCH METHODS

Identifiers

PMID27059469
PMCPMC4838736

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.