Evidence map›Paper›PMID 27059425›Full record

ArticleAdvanced healthcare materials2016

Guided Homing of Cells in Multi-Photon Microfabricated Bioscaffolds.

Mark A Skylar-Scott, Man-Chi Liu, Yuelong Wu, Atray Dixit, Mehmet Fatih Yanik

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Lithography-based 3D printing of hydrogels.Nature reviews bioengineering · 2025
    Article
  4. Article
  5. Review
  6. Advances in Skin Tissue Engineering and Regenerative Medicine.Journal of burn care & research : official publication of the American Burn Association · 2023
    Article
  7. Light-based vat-polymerization bioprinting.Nature reviews. Methods primers · 2023
    Article
  8. Review
  9. Beyond the Threshold: A Study of Chalcogenophene-Based Two-Photon Initiators.Chemistry of materials : a publication of the American Chemical Society · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Engineering Organoid Vascularization.Frontiers in bioengineering and biotechnology · 2019
    Review
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mark A Skylar-ScottHarvard John A. Paulson School of Engineering and Applied Science, Harvard University, Cambridge, MA, 02138, USA.
Man-Chi LiuResearch Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Yuelong WuResearch Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Atray DixitResearch Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Mehmet Fatih YanikResearch Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.

Funding

Generating transplantable neurons by in vivo combinatorial screening of transcripDP1NS082101 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YANIK, MEHMET FATIH · 2012 to 2015
$3.2M
High-throughput single-cell-resolution genetic and pharmacological screens usingR01NS066352 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YANIK, MEHMET FATIH · 2009 to 2012
$1.7M
Generating transplantable neurons by in vivo combinatorial screening of transcripDP1OD008161 · OD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI YANIK, MEHMET FATIH · 2011 to 2011
$803k
NIH HHS DP1 OD008161NINDS NIH HHS DP1 NS082101NINDS NIH HHS R01 NS066352
6 · The paper itself

Abstract

Tissues contain exquisite vascular microstructures, and patterns of chemical cues for directing cell migration, homing, and differentiation for organ development and function. 3D microfabrication by multi-photon photolithography is a flexible, high-resolution tool for generating 3D bioscaffolds. However, the combined fabrication of scaffold microstructure simultaneously with patterning of cues to create both geometrically and chemically defined microenvironments remains to be demonstrated. This study presents a high-speed method for micron-resolution fabrication of scaffold microstructure and patterning of protein cues simultaneously using native scaffold materials. By the simultaneous microfabrication of arbitrary microvasculature geometries, and patterning selected regions of the microvasculature with the homing ligand P-selectin, this study demonstrates adhesion, rolling, and selective homing of cells in defined 3D regions. This novel ability to generate high-resolution geometries replete with patterned cues at high speed enables the construction of biomimetic microenvironments for complex 3D assays of cellular behavior.

Indexed as

Biocompatible MaterialsBiomimeticsCells, CulturedHL-60 CellsHumansMicrotechnologyPhotonsP-SelectinTissue EngineeringTissue ScaffoldsBiocompatible MaterialsP-Selectin3D Printingcapillary networkcell rollingcell trapsengineered microvasculature

Identifiers

PMID27059425
PMCPMC6070392

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.