ArticleJournal of molecular evolution2016
Dosage Compensation and the Distribution of Sex-Biased Gene Expression in Drosophila: Considerations and Genomic Constraints.
Article in Journal of molecular evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Induction and inhibition of Drosophila X chromosome gene expression are both impeded by the dosage compensation complex.G3 (Bethesda, Md.) · 2022Article
- The Influence of Chromosomal Environment on X-Linked Gene Expression in Drosophila melanogaster.Genome biology and evolution · 2020Article
- A gene's-eye view of sexual antagonism.Proceedings. Biological sciences · 2020Article
- X-linkage is not a general inhibitor of tissue-specific gene expression in Drosophila melanogaster.Heredity · 2017Article
- Comparative Transcriptomics of Malaria Mosquito Testes: Function, Evolution, and Linkage.G3 (Bethesda, Md.) · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Several studies in Drosophila have shown a paucity of male-biased genes (i.e., genes that express higher in males than in females) on the X chromosome. Dosage compensation (DC) is a regulatory mechanism of gene expression triggered in males that hypertranscribes the X-linked genes to the level of transcription in females. There are currently two different hypotheses about the effects of DC on the distribution of male-biased genes: (1) it might limit male-expression level, or (2) it might interfere with the male upregulation of gene expression. Here, we used previously published gene expression datasets to reevaluate both hypotheses and introduce a mutually exclusive prediction that helped us to reject the hypothesis that the paucity of male-biased genes in the X chromosome is due to a limit in the male-expression level. Our analysis also uncovers unanticipated details about how DC interferes with the genomic distribution of both, male-biased and female-biased genes. We suggest that DC actually interferes with female downregulation of gene expression and not male upregulation, as previously suggested.
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Registered trials
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