ArticlePLoS pathogens2016
Revealing the Micro-scale Signature of Endemic Zoonotic Disease Transmission in an African Urban Setting.
Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 87 citations in OpenAlex.
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- A time-space Bayesian regression model of rabies cases in the animal population of Kazakhstan (2013-2023).Frontiers in veterinary science · 2025Article
- Combining genomics and epidemiology to investigate a zoonotic outbreak of rabies in Romblon Province, Philippines.Nature communications · 2024Article
- Genomic Characterization of a Dog-Mediated Rabies Outbreak in El Pedregal, Arequipa, Peru.bioRxiv : the preprint server for biology · 2024Article
- Benefit-cost analysis of coordinated strategies for control of rabies in Africa.Nature communications · 2023Article
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- Understanding the incidence and timing of rabies cases in domestic animals and wildlife in south-east Tanzania in the presence of widespread domestic dog vaccination campaigns.Veterinary research · 2022Article
- Real-time estimation of the epidemic reproduction number: Scoping review of the applications and challenges.PLOS digital health · 2022Article
- Elimination of human rabies in Goa, India through an integrated One Health approach.Nature communications · 2022Article
- Making genomic surveillance deliver: A lineage classification and nomenclature system to inform rabies elimination.PLoS pathogens · 2022Article
- Rabies shows how scale of transmission can enable acute infections to persist at low prevalence.Science (New York, N.Y.) · 2022Article
- Molecular analyses of human rabies virus associated with encephalitis in two children in Gabon.IJID regions · 2022Article
- Incidence and seroprevalence of rabies virus in humans, dogs and other animal species in Africa, a systematic review and meta-analysis.One health (Amsterdam, Netherlands) · 2021Review
- Deciphering early-warning signals of SARS-CoV-2 elimination and resurgence from limited data at multiple scales.Journal of the Royal Society, Interface · 2021Article
- Modelling the influence of naturally acquired immunity from subclinical infection on outbreak dynamics and persistence of rabies in domestic dogs.PLoS neglected tropical diseases · 2021Article
- Mathematical modelling and phylodynamics for the study of dog rabies dynamics and control: A scoping review.PLoS neglected tropical diseases · 2021Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 5 countries.
Funding
Abstract
The development of novel approaches that combine epidemiological and genomic data provides new opportunities to reveal the spatiotemporal dynamics of infectious diseases and determine the processes responsible for their spread and maintenance. Taking advantage of detailed epidemiological time series and viral sequence data from more than 20 years reported by the National Reference Centre for Rabies of Bangui, the capital city of Central African Republic, we used a combination of mathematical modeling and phylogenetic analysis to determine the spatiotemporal dynamics of rabies in domestic dogs as well as the frequency of extinction and introduction events in an African city. We show that although dog rabies virus (RABV) appears to be endemic in Bangui, its epidemiology is in fact shaped by the regular extinction of local chains of transmission coupled with the introduction of new lineages, generating successive waves of spread. Notably, the effective reproduction number during each wave was rarely above the critical value of 1, such that rabies is not self-sustaining in Bangui. In turn, this suggests that rabies at local geographic scales is driven by human-mediated dispersal of RABV among sparsely connected peri-urban and rural areas as opposed to dispersion in a relatively large homogenous urban dog population. This combined epidemiological and genomic approach enables development of a comprehensive framework for understanding disease persistence and informing control measures, indicating that control measures are probably best targeted towards areas neighbouring the city that appear as the source of frequent incursions seeding outbreaks in Bangui.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.