ArticlePLoS neglected tropical diseases2016
Comparison of the Performance of the TPTest, Tubex, Typhidot and Widal Immunodiagnostic Assays and Blood Cultures in Detecting Patients with Typhoid Fever in Bangladesh, Including Using a Bayesian Latent Class Modeling Approach.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Achieving accurate laboratory diagnosis of typhoid fever: a review and meta-analysis of TUBEX® TF clinical performance.Pathogens and global health · 2019Pooled it
- Comparative accuracy of typhoid diagnostic tools: A Bayesian latent-class network analysis.PLoS neglected tropical diseases · 2019Pooled it
- Rapid diagnostic tests for typhoid and paratyphoid (enteric) fever.The Cochrane database of systematic reviews · 2017Pooled it
- Article
- Clinical characteristics of enteric fever and performance of TUBEX TF IgM test in Indonesian hospitals.PLoS neglected tropical diseases · 2024Article
- Review
- Comparative Analysis of Commercially Available Typhoid Point-of-Care Tests: Results of a Prospective and Hybrid Retrospective Multicenter Diagnostic Accuracy Study in Kenya and Pakistan.Journal of clinical microbiology · 2022Article
- Understanding the Mechanism of Antimicrobial Resistance and Pathogenesis ofMicroorganisms · 2022Review
- Article
- Article
- Enteric Fever Diagnosis: Current Challenges and Future Directions.Pathogens (Basel, Switzerland) · 2021Review
- Gold Standard Cholera Diagnostics Are Tarnished by Lytic Bacteriophage and Antibiotics.Journal of clinical microbiology · 2020Article
- Case Report:The American journal of tropical medicine and hygiene · 2020Article
- Laboratory Diagnosis of Paratyphoid Fever: Opportunity of Surface Plasmon Resonance.Diagnostics (Basel, Switzerland) · 2020Review
- Evaluation of a Rapid Point-of-Care Multiplex Immunochromatographic Assay for the Diagnosis of Enteric Fever.mSphere · 2020Article
- How Can the Typhoid Fever Surveillance in Africa and the Severe Typhoid Fever in Africa Programs Contribute to the Introduction of Typhoid Conjugate Vaccines?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Instrument-Free and Visual Detection ofInternational journal of molecular sciences · 2019Article
- Plasma Immunoglobulin A Responses Against 2 Salmonella Typhi Antigens Identify Patients With Typhoid Fever.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Redefining typhoid diagnosis: what would an improved test need to look like?BMJ global health · 2019Article
- Typhoid and paratyphoid fever: a call to action.Current opinion in infectious diseases · 2018Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThere is an urgent need for an improved diagnostic assay for typhoid fever. In this current study, we compared the recently developed TPTest (Typhoid and Paratyphoid Test) with the Widal test, blood culture, and two commonly used commercially available kits, Tubex and Typhidot. METHODOLOGY: For analysis, we categorized 92 Bangladeshi patients with suspected enteric fever into four groups: S. Typhi bacteremic patients (n = 28); patients with a fourfold change in Widal test from day 0 to convalescent period (n = 7); patients with Widal titer ≥1:320 (n = 13) at either acute or convalescent stage of disease; and patients suspected with enteric fever, but with a negative blood culture and Widal titer (n = 44). We also tested healthy endemic zone controls (n = 20) and Bangladeshi patients with other febrile illnesses (n = 15). Sample size was based on convenience to facilitate preliminary analysis. PRINCIPLE
findingsOf 28 S. Typhi bacteremic patients, 28 (100%), 21 (75%) and 18 (64%) patients were positive by TPTest, Tubex and Typhidot, respectively. In healthy endemic zone controls, the TPTest method was negative in all, whereas Tubex and Typhidot were positive in 3 (15%) and 5 (25%), respectively. We then estimated sensitivity and specificity of all diagnostic tests using Bayesian latent class modeling. The sensitivity of TPTest, Tubex and Typhidot were estimated at 96.0% (95% CI: 87.1%-99.8%), 60.2% (95% CI: 49.3%-71.2%), and 59.6% (95% CI: 50.1%-69.3%), respectively. Specificity was estimated at 96.6% (90.7%-99.2%) for TPTest, 89.9% (79.6%-96.8%) for Tubex, and 80.0% (67.7%-89.7%) for Typhidot.
conclusionThese results suggest that the TPTest is highly sensitive and specific in diagnosing individuals with typhoid fever in a typhoid endemic setting, outperforming currently available and commonly used alternatives.
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