Evidence map›Paper›PMID 27058657›Full record

ArticleCell2016

Insulin Signaling in a Bit of a Jam.

Vassily I Kutyavin, Ajay Chawla

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vassily I KutyavinCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-9001, USA.
Ajay ChawlaCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94158-9001, USA; Departments of Physiology and Medicine, University of California, San Francisco, San Francisco, CA 94158-9001, USA. Electronic address: ajay.chawla@ucsf.edu.
University of California, San Francisco · US

Funding

DIABETES, ENDOCRINOLOGY &METABOLISM TRAINING PROGRAMT32DK007418 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARD C HSIAO · 1986 to 2026
$14.3M
Immune Triggers of Tissue RegenerationDP1OD006415 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAWLA, AJAY · 2009 to 2011
$2.4M
Myeloid Cell Functions in Obesity and Diabetes.R01DK101064 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAWLA, AJAY · 2015 to 2018
$1.6M
Immune Triggers of Tissue RegenerationDP1AR064158 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAWLA, AJAY · 2012 to 2013
$1.5M
NIAMS NIH HHS DP1 AR064158NIDDK NIH HHS R01 DK101064NIDDK NIH HHS T32 DK007418NIH HHS DP1 OD006415
6 · The paper itself

Abstract

In this issue of Cell, Okin and Medzhitov report that sustained inflammation promotes hyperglycemia by targeting the mevalonate pathway. This represents an important step forward in understanding the mechanisms underlying the association between chronic low-grade inflammation and disruption of normal tissue functions in metabolic diseases.

Indexed as

InsulinHumansHyperglycemiaInflammationMetabolic DiseasesSignal TransductionInsulin

Identifiers

PMID27058657
OpenAlexW2318616697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.