ArticlePloS one2016
Potassium Uptake Mediated by Trk1 Is Crucial for Candida glabrata Growth and Fitness.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Trk1 potassium transport is crucial for effectiveProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Review
- Article
- Genome sequencing ofPeerJ · 2020Article
- Trk1, the sole potassium-specific transporter in Candida glabrata, contributes to the proper functioning of various cell processes.World journal of microbiology & biotechnology · 2019Article
- Trk1-mediated potassium uptake contributes to cell-surface properties and virulence of Candida glabrata.Scientific reports · 2019Article
- Four Saccharomyces species differ in their tolerance to various stresses though they have similar basic physiological parameters.Folia microbiologica · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The maintenance of potassium homeostasis is crucial for all types of cells, including Candida glabrata. Three types of plasma-membrane systems mediating potassium influx with different transport mechanisms have been described in yeasts: the Trk1 uniporter, the Hak cation-proton symporter and the Acu ATPase. The C. glabrata genome contains only one gene encoding putative system for potassium uptake, the Trk1 uniporter. Therefore, its importance in maintaining adequate levels of intracellular potassium appears to be critical for C. glabrata cells. In this study, we first confirmed the potassium-uptake activity of the identified gene's product by heterologous expression in a suitable S. cerevisiae mutant, further we generated a corresponding deletion mutant in C. glabrata and analysed its phenotype in detail. The obtained results show a pleiotropic effect on the cell physiology when CgTRK1 is deleted, affecting not only the ability of trk1Δ to grow at low potassium concentrations, but also the tolerance to toxic alkali-metal cations and cationic drugs, as well as the membrane potential and intracellular pH. Taken together, our results find the sole potassium uptake system in C. glabrata cells to be a promising target in the search for its specific inhibitors and in developing new antifungal drugs.
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