Evidence map›Paper›PMID 27058594›Full record

ArticleOptometry and vision science : official publication of the American Academy of Optometry2016

Variability and Errors of Manually Digitized Goldmann Visual Fields.

Michael P Barry, Ava K Bittner, Liancheng Yang, Rebecca Marcus, Mian Haris Iftikhar, Gislin Dagnelie

Registry-linked trialAbstract read
In one paragraph

Article in Optometry and vision science : official publication of the American Academy of Optometry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07185971 (PAVE), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07185971 narecruitingnot on this mapstarted 2026, after this paper: background citation

PAVE (Parallactic Visual-Field Enhancement) System for Treatment of Chronic Visual Field Loss

TypeinterventionalSponsorNeuroAEye LLCRan2026 to 2026Enrolled20ConditionsHomonymous Hemianopsia, Homonymous QuadrantanopiaArmsPAVE (Parallactic Visual-Field Enhancement) treatment using a virtual reality head mounted display
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Longevity of visual improvements following transcorneal electrical stimulation and efficacy of retreatment in three individuals with retinitis pigmentosa.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018
    Trial
  3. Article
  4. Retinitis Pigmentosa: Current Clinical Management and Emerging Therapies.International journal of molecular sciences · 2023
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael P Barry*MS †OD, PhD, FAAO ‡BA §MD **PhD, FAAO Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland (MPB); College of Optometry, Nova Southeastern University, Ft. Lauderdale, Florida (AKB); and Department of Ophthalmology (LY, MHI, GD) and Department of Neuroscience, Johns Hopkins University, Baltimore, Maryland (RM).
Ava K Bittner
Liancheng Yang
Rebecca Marcus
Mian Haris Iftikhar
Gislin Dagnelie

Funding

Visual Science Training ProgramT32EY007143 · NEI · JOHNS HOPKINS UNIVERSITY · PI Laura Ensign, JEREMY NATHANS · 1995 to 2026
$6.2M
Training in Clinical Trials for Subjects with Low VisionK23EY018356 · NEI · JOHNS HOPKINS UNIVERSITY · PI BITTNER, AVA K · 2007 to 2011
$784k
NEI NIH HHS K23 EY018356NEI NIH HHS T32 EY007143
6 · The paper itself

Abstract

purposeGoldmann visual fields (GVFs) are useful for tracking changes in areas of functional retina, including the periphery, in inherited retinal degeneration patients. Quantitative GVF analysis requires digitization of the chart coordinates for the main axes and isopter points marked by the GVF operator during testing. This study investigated inter- and intra-digitizer variability among users of a manual GVF digitization program.

methodsTen digitizers were trained for 1 hour, then digitized 23 different GVFs from inherited retinal degeneration patients in each of three testing blocks. Digitizers labeled each isopter as seeing or non-seeing, and its target size. Isopters with the same test target within each GVF were grouped to create isopter groups.

resultsThe standard deviation of isopter group area showed an approximate square-root relationship with total isopter group area. Accordingly, the coefficient of variation for isopter group area decreased from 68% to 0.2% with increasing isopter group area. A bootstrap version of ANOVA did not reveal a significant effect of digitizers on isopter group area. Simulations involving random sampling of digitizers showed that five to seven digitizers would be required to catch 95% to 99% of labeling errors and isopter misses, on the basis of data discrepancies, with 99% probability.

conclusionsThese data suggest that any minimally trained digitizer would be capable of reliably determining any isopter area, regardless of size. Studies using this software could either use five to seven minimally trained digitizers for each GVF, three digitizers who demonstrate low frequencies of errors on a practice set of GVFs, or two digitizers with an expert reader to adjudicate discrepancies and catch errors.

Indexed as

Diagnostic ErrorsAdolescentAdultFemaleHumansLeber Congenital AmaurosisMaleProbabilityRetinaRetinal DegenerationRetinitis PigmentosaSoftwareVision DisordersVisual FieldsVisual Field TestsYoung Adult

Identifiers

PMID27058594
PMCPMC4915992

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.