Evidence map›Paper›PMID 27058579›Full record

ArticleJournal of burn care & research : official publication of the American Burn Association

Apyrase Elicits Host Antimicrobial Responses and Resolves Infection in Burns.

Jill M Bayliss, Benjamin Levi, Jianfeng Wu, Stewart C Wang, Grace L Su, Chuanwu Xi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of burn care & research : official publication of the American Burn Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jill M BaylissFrom the *Departments of Internal Medicine, †Environmental Health Sciences, ‡Surgery, University of Michigan, Ann Arbor; and §Department of Medicine, VA Ann Arbor Health Systems, Michigan.
Benjamin Levi
Jianfeng Wu
Stewart C Wang
Grace L Su
Chuanwu Xi
University of Michigan–Ann Arbor · USNational Center for Injury Prevention and Control · US

Funding

Extracellular ATP in biofilm formation and wound infectionR01GM098350 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI XI, CHUANWU · 2011 to 2015
$1.4M
Novel Pathway and Prevention Strategy for Heterotopic OssificationK08GM109105 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEVI, BENJAMIN · 2014 to 2017
$785k
NIGMS NIH HHS K08 GM109105NIGMS NIH HHS R01 GM098350
6 · The paper itself

Abstract

The authors previously reported that adenosine triphosphate (ATP) stimulates biofilm formation and removal of the ATP could reduce biofilm formation. The main objective of this study was to evaluate the effects of the ATP-hydrolyzing enzyme, apyrase, on control of Acinetabacter baumannii infection in the burn wound as well as to assess host skin antimicrobial responses. The authors found that apyrase stimulated nitric oxide formation at the wound site and reduced CD55 expression, thereby inducing the assembly of membrane attack complexes. Apyrase treatment nearly eradicated multidrug-resistant A. baumannii from burn wounds in the absence of antibiotics. Apyrase may be an effective therapy against antibiotic-resistant bacterial infections in burns.

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAdenosine TriphosphateAnimalsAnti-Bacterial AgentsApyraseBurnsDrug Resistance, Multiple, BacterialFemaleMice, Inbred C57BLWound InfectionAdenosine TriphosphateAnti-Bacterial AgentsApyrase

Identifiers

PMID27058579
PMCPMC5086290
OpenAlexW2353620147

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.