ArticleJournal of occupational and environmental medicine2016
Measured Pulmonary and Systemic Markers of Inflammation and Oxidative Stress Following Wildland Firefighter Simulations.
Article in Journal of occupational and environmental medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Changes in Serum Proteins in Firefighters Responding to the 2025 Los Angeles Urban Conflagrations.Journal of occupational and environmental medicine · 2026Article
- Evaluating urinary metabolic profiles with wildland-urban-interface (wui) fire exposure among male firefighters: a comparison with municipal structure fires (msf).Environmental health : a global access science source · 2025Article
- Urban Lifestyle and Climate-Driven Environmental Exposures: Immunological Consequences for Pediatric Respiratory Allergies.Immunity, inflammation and disease · 2025Review
- Effect of prednisone on woodsmoke-induced sputum inflammation in healthy volunteers: A randomized, placebo-controlled pilot study.The journal of allergy and clinical immunology. Global · 2025Article
- Controlled human exposures: a review and comparison of the health effects of diesel exhaust and wood smoke.Particle and fibre toxicology · 2024Review
- Mechanisms of climate change and related air pollution on the immune system leading to allergic disease and asthma.Seminars in immunology · 2023Review
- Granzymes, IL-16, and poly(ADP-ribose) polymerase 1 increase during wildfire smoke exposure.The journal of allergy and clinical immunology. Global · 2023Article
- Effects of wildfire smoke PM2.5 on indicators of inflammation, health, and metabolism of preweaned Holstein heifers.Journal of animal science · 2023Article
- Human and planetary health on fire.Nature reviews. Immunology · 2022Article
- Application of a Novel Collection of Exhaled Breath Condensate to Exercise Settings.International journal of environmental research and public health · 2022Article
- Health risks and mitigation strategies from occupational exposure to wildland fire: a scoping review.Journal of occupational medicine and toxicology (London, England) · 2022Article
- Respiratory Impacts of Wildland Fire Smoke: Future Challenges and Policy Opportunities. An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2021Article
- Controlled human exposures to wood smoke: a synthesis of the evidence.Particle and fibre toxicology · 2020Review
- Mechanisms of lung toxicity induced by biomass burning aerosols.Particle and fibre toxicology · 2020Article
- Measuring acute pulmonary responses to occupational wildland fire smoke exposure using exhaled breath condensate.Archives of environmental & occupational health · 2020Article
- Acute Effects on Blood Pressure Following Controlled Exposure to Cookstove Air Pollution in the STOVES Study.Journal of the American Heart Association · 2019Article
- Experimental Woodsmoke Exposure During Exercise and Blood Oxidative Stress.Journal of occupational and environmental medicine · 2018Article
- Impact of Work Task-Related Acute Occupational Smoke Exposures on Select Proinflammatory Immune Parameters in Wildland Firefighters.Journal of occupational and environmental medicine · 2017Article
- Potential Harmful Effects of PM2.5 on Occurrence and Progression of Acute Coronary Syndrome: Epidemiology, Mechanisms, and Prevention Measures.International journal of environmental research and public health · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveA controlled human exposure study was conducted to investigate the impact of inhalational exposures to wood smoke PM2.5 on measured concentrations of airway and systemic inflammatory biomarkers.
methodsMimicking wildland firefighter activities, 10 participants were exposed to three doses of wood smoke PM2.5 (filtered-air, 250 μg/m, and 500 μg/m) while exercising on a treadmill. Exhaled breath condensate (EBC) and blood plasma samples were obtained pre-, immediately post-, and 1-hour postexposure. 8-isoprostane, pH, and myeloperoxidase were measured in EBC, while H2O2, surfactant protein D, and pentraxin-3 (PTX3) were measured in both EBC and plasma.
resultsOnly pH, 8-isoprostane, and PTX3 displayed significant changes when comparing pre- and postexposures.
conclusionsMarkers of inflammation and oxidative stress, including PTX3, pH, and 8-isoprostane in EBC and/or plasma, are sensitive to wood smoke inhalation, with further investigations warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.