ArticleAIDS (London, England)2016
Option A improved HIV-free infant survival and mother to child HIV transmission at 9-18 months in Zimbabwe.
Article in AIDS (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Augmenting progress on the elimination of vertical transmissions of HIV in India: Insights from Spectrum-based HIV burden estimations.PLOS global public health · 2023Article
- 24-Month HIV-free survival among HIV-exposed Infants in Lesotho: the PEAWIL cohort study.Journal of the International AIDS Society · 2020Observational
- Using the critical path method to rollout and optimise new PMTCT guidelines to eliminate mother-to-child transmission of HIV in Zimbabwe: a descriptive analysis.BMC health services research · 2020Article
- Use of data from various sources to evaluate and improve the prevention of mother-to-child transmission of HIV programme in Zimbabwe: a data integration exercise.Journal of the International AIDS Society · 2020Article
- Costs and economies of scale in the accelerated program for prevention of mother-to-child transmission of HIV in Zimbabwe.PloS one · 2020Article
- HIV-free survival among breastfed infants born to HIV-positive women in northern Uganda: a facility-based retrospective study.The Pan African medical journal · 2020Article
- Protocol for the evaluation of the population-level impact of Zimbabwe's prevention of mother-to-child HIV transmission program option B+: a community based serial cross-sectional study.BMC pregnancy and childbirth · 2019Article
- Infant Human Immunodeficiency Virus-free Survival in the Era of Universal Antiretroviral Therapy for Pregnant and Breastfeeding Women: A Community-based Cohort Study From Rural Zambia.The Pediatric infectious disease journal · 2018Article
- Mother-to-Child Transmission of HIV and HIV-Free Survival in Swaziland: A Community-Based Household Survey.AIDS and behavior · 2018Article
- Impact of Timing of Antiretroviral Treatment and Birth Weight on Mother-to-Child Human Immunodeficiency Virus Transmission: Findings From an 18-Month Prospective Cohort of a Nationally Representative Sample of Mother-Infant Pairs During the Transition From Option A to Option B+ in Zimbabwe.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2018Observational
- PMTCT Service Uptake Among Adolescents and Adult Women Attending Antenatal Care in Selected Health Facilities in Zimbabwe.Journal of acquired immune deficiency syndromes (1999) · 2017Article
- Improving estimates of children living with HIV from the Spectrum AIDS Impact Model.AIDS (London, England) · 2017Article
- Time to Consider Moving Beyond Exclusive Breastfeeding in Southern Africa.Children (Basel, Switzerland) · 2017Article
- International Congress of Drug Therapy in HIV Infection 23-26 October 2016, Glasgow, UK.Journal of the International AIDS Society · 2016Article
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13 authors.
Funding
Abstract
objectiveWe evaluated the impact of Option A on HIV-free infant survival and mother-to-child transmission (MTCT) in Zimbabwe.
designSerial cross-sectional community-based serosurveys.
methodsWe analyzed serosurvey data collected in 2012 and 2014 among mother-infant pairs from catchment areas of 132 health facilities from five of 10 provinces in Zimbabwe. Eligible infants (alive or deceased) were born 9-18 months before each survey to mothers at least 16 years old. We randomly selected mother-infant pairs and conducted questionnaires, verbal autopsies, and collected blood samples. We estimated the HIV-free infant survival and MTCT rate within each catchment area and compared the 2012 and 2014 estimates using a paired t test and number of HIV infections averted because of the intervention.
resultsWe analyzed 7249 mother-infant pairs with viable maternal specimens collected in 2012 and 8551 in 2014. The mean difference in the catchment area level MTCT between 2014 and 2012 was -5.2 percentage points (95% confidence interval = -8.1, -2.3, P < 0.001). The mean difference in the catchment area level HIV-free survival was 5.5 percentage points (95% confidence interval = 2.6, 8.5, P < 0.001). Between 2012 and 2014, 1779 infant infections were averted compared with the pre-Option A regimen. The association between HIV-free infant survival and duration of Option A implementation was NS at the multivariate level (P = 0.093).
conclusionWe found a substantial and statistically significant increase in HIV-free survival and decrease in MTCT among infants aged 9-18 months following Option A rollout in Zimbabwe. This is the only evaluation of Option A and shows the effectiveness of Option A and Zimbabwe's remarkable progress toward eMTCT.
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