Evidence map›Paper›PMID 27058161›Full record

ArticleThe journal of pain2016

Distress Intolerance and Prescription Opioid Misuse Among Patients With Chronic Pain.

R Kathryn McHugh, Roger D Weiss, Marise Cornelius, Marc O Martel, Robert N Jamison, Robert R Edwards

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in The journal of pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05639712 (Understanding Opioid Use Before and After Surgery in Norway), which is not on this map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05639712 phase4completednot on this mapstarted 2022, after this paper: background citation

Understanding Opioid Use Before and After Surgery in Norway: A Prospective Multicenter Study and Randomized Double-blind Controlled Study

TypeinterventionalSponsorOslo University HospitalRan2022 to 2025Enrolled1,020ConditionsOpioid Use, Affective SymptomsArmsPlacebo, Morphine 2.5 mg i.v., Morphine 5 mg i.v., Morphine 10 mg i.v., Oxycodone 2.5 mg i.v.
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 87 citations in OpenAlex.

  1. Effects of behavioral interventions on stress reactivity in adults with substance use disorders.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024
    Trial
  2. Trial
  3. Article
  4. Article
  5. The role of distress tolerance in the momentary relationship between negative affect and drinking in daily life.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Perceived discrimination and problematic opioid use among Black individuals with chronic musculoskeletal pain.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024
    Article
  14. Observational
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Distress tolerance among emergency department patients in acute pain: Associations with substance use treatment.Stress and health : journal of the International Society for the Investigation of Stress · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

R Kathryn McHughDivision of Alcohol and Drug Abuse, McLean Hospital, Belmont, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts. Electronic address: kmchugh@mclean.harvard.edu.
Roger D WeissDivision of Alcohol and Drug Abuse, McLean Hospital, Belmont, Massachusetts; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.
Marise CorneliusPain Management Center, Brigham and Women's Hospital, Chestnut Hill, Massachusetts.
Marc O MartelPain Management Center, Brigham and Women's Hospital, Chestnut Hill, Massachusetts; Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts.
Robert N JamisonDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts; Pain Management Center, Brigham and Women's Hospital, Chestnut Hill, Massachusetts; Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts.
Robert R EdwardsDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts; Pain Management Center, Brigham and Women's Hospital, Chestnut Hill, Massachusetts; Department of Anesthesiology, Harvard Medical School, Boston, Massachusetts.
Brigham and Women's Hospital · USHarvard University · US

Funding

The National Drug Abuse Treatment Clinical Trials NetworkUG1DA015831 · NIDA · YALE UNIVERSITY · PI Gail D'Onofrio, Roger D. Weiss · 2015 to 2026
$110.8M
Brain Mechanisms Underlying CBT-Related Reductions in FibromyalgiaR01AR064367 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI EDWARDS, ROBERT R, NAPADOW, VITALY · 2014 to 2018
$4.0M
Biobehavioral Risk Factors for Persistent Pain following Total Knee ArthroplastyR01AG034982 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI EDWARDS, ROBERT R · 2010 to 2014
$3.2M
Mentoring in Drug Abuse and Dual Diagnosis ResearchK24DA022288 · NIDA · MCLEAN HOSPITAL · PI WEISS, ROGER D. · 2007 to 2016
$1.8M
Opioid-induced change in pain sensitivity and modulation: Links to opioid misuseR21DA041020 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI EDWARDS, ROBERT R · 2016 to 2017
$488k
Distress Intolerance and Prescription Opioid Abuse in Chronic Pain PatientsR03DA034102 · NIDA · MCLEAN HOSPITAL · PI MCHUGH, REBECCA KATHRYN · 2012 to 2012
$138k
NIAMS NIH HHS R01 AR064367NIA NIH HHS R01 AG034982NIDA NIH HHS K24 DA022288NIDA NIH HHS R03 DA034102NIDA NIH HHS R21 DA041020NIDA NIH HHS UG1 DA015831
6 · The paper itself

Abstract

unlabelledThe risk for misuse of opioid medications is a significant challenge in the management of chronic pain. The identification of those who may be at greater risk for misusing opioids is needed to facilitate closer monitoring of high-risk subgroups, and may help to identify therapeutic targets for mitigating this risk. The aim of this study was to examine whether distress intolerance-the perceived or actual inability to manage negative emotional and somatic states-was associated with opioid misuse in those with chronic pain. A sample of 51 participants prescribed opioid analgesics for chronic back or neck pain were recruited for a 1-time laboratory study. Participants completed measures of distress intolerance and opioid misuse, and a quantitative sensory testing battery. Results suggested that distress intolerance was associated with opioid misuse, even controlling for pain severity and negative affect. Distress intolerance was not associated with pain severity, threshold, or tolerance, but was associated with self-reported anxiety and stress after noxious stimuli. This study found robust differences in distress intolerance between adults with chronic pain with and without opioid medication misuse. Distress intolerance may be a relevant marker of risk for opioid misuse among those with chronic pain. PERSPECTIVE: This study demonstrated that distress intolerance was associated with opioid misuse in adults with chronic pain who were prescribed opioids. Distress intolerance can be modified with treatment, and thus may be relevant not only for identification of risk for opioid misuse, but also for mitigation of this risk.

Indexed as

AdolescentAdultAgedAnalgesics, OpioidCatastrophizationChronic PainFemaleHumansHyperalgesiaMaleMiddle AgedOpioid-Related DisordersPain MeasurementPain PerceptionPain ThresholdPrescription Drug MisuseAnalgesics, Opioidchronic paindistress toleranceopioid misuseOpioids

Identifiers

PMID27058161
PMCPMC4925301
OpenAlexW2313355562

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.