ArticleAmerican journal of perinatology2016
Symptomatic Postnatal Cytomegalovirus Testing among Very Low-Birth-Weight Infants: Indications and Outcomes.
Article in American journal of perinatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Association between viral infection and bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis.European journal of pediatrics · 2024Pooled it
- Transmission of cytomegalovirus via breast milk in low birth weight and premature infants: a systematic review and meta-analysis.BMC pediatrics · 2021Pooled it
- Article
- Postnatally Acquired Neonatal CMV Infection in Preterm Infants: From a Case Series to a Narrative Review of the Literature.Children (Basel, Switzerland) · 2025Review
- Respiratory virome in hospitalized children and analysis of its correlation with disease severity.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Postnatal cytomegalovirus infections did not alter amplitude-integrated electroencephalography signals or general movements in preterm infants.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Breast Milk and Saliva Lactoferrin Levels and Postnatal Cytomegalovirus Infection.American journal of perinatology · 2021Article
- Optimizing Early Neonatal Nutrition and Dietary Pattern in Premature Infants.International journal of environmental research and public health · 2021Review
- Impact of breast milk-acquired cytomegalovirus infection in premature infants: Pathogenesis, prevention, and clinical consequences?Reviews in medical virology · 2020Review
- Association of Adverse Hearing, Growth, and Discharge Age Outcomes With Postnatal Cytomegalovirus Infection in Infants With Very Low Birth Weight.JAMA pediatrics · 2020Article
- Observational study of cytomegalovirus from breast milk and necrotising enterocolitis.Archives of disease in childhood. Fetal and neonatal edition · 2019Article
- Challenges and Clinical Implications of the Diagnosis of Cytomegalovirus Lung Infection in Children.Current infectious disease reports · 2019Review
- Controversies in Breastfeeding.Frontiers in pediatrics · 2018Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Objective The objective of this study was to describe the indications for postnatal cytomegalovirus (CMV) testing among very low-birth-weight (VLBW, birth weight [BW] < 1,500 g) infants, clinical characteristics of infected infants, and adverse outcomes associated with CMV infection. Study Design This is a single-center, retrospective study of 2,132 VLBW infants from 1999 to 2013. Results In this study, 145 (6.8%) infants out of 2,132 were evaluated for postnatal CMV infection and 27 (18.6%) infants out of 145 were infected. CMV-tested infants were of significantly lower gestational age and BW compared with untested VLBW infants (p < 0.001). Respiratory decompensation and thrombocytopenia were the findings most commonly associated with infection. CMV-infected infants had significantly more exposure to mechanical ventilation and longer duration of hospitalization. Adjusting for multiple predictors of respiratory morbidity, the incidence of bronchopulmonary dysplasia (BPD) was significantly elevated among infants diagnosed with postnatal CMV infection (odds ratio, 4.0 [95% confidence interval, 1.3-12.4); p, 0.02.) Conclusion Symptomatic postnatal CMV infection was diagnosed in 1.3% of VLBW infants, most commonly among infants with BW < 1,000 g with respiratory instability and thrombocytopenia. Similar to late-onset bacterial infection, symptomatic postnatal CMV infection may be an independent contributor to the development of BPD. This possibility should be addressed in a prospective study of extremely low BW infants.
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Registered trials
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