ArticlePloS one2016
A Simple, Realistic Stochastic Model of Gastric Emptying.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Stochastic Differential Equations (SDEs) in NONMEM for Probing Population Pharmacokinetic Model Misspecification: Diagnostic Utility, Practical Considerations, and Future Directions.The AAPS journal · 2026Article
- A novel compartmental approach for modeling stomach motility and gastric emptying.Computers in biology and medicine · 2024Article
- A physiologically-based digital twin for alcohol consumption-predicting real-life drinking responses and long-term plasma PEth.NPJ digital medicine · 2024Article
- Physiological Dynamics in the Upper Gastrointestinal Tract and the Development of Gastrointestinal Absorption Models for the Immediate-Release Oral Dosage Forms in Healthy Adult Human.Pharmaceutical research · 2023Review
- Stochastic Differential Equation-based Mixed Effects Model of the Fluid Volume in the Fasted Stomach in Healthy Adult Human.The AAPS journal · 2023Article
- Cross Effects of Diets and Rearing Temperatures on Gastrointestinal Evacuation and Growth Performance in Adult Sabah Groupers (Animals : an open access journal from MDPI · 2022Article
- Review
- A quantitative model for metabolic intervention using gut microbes.Biotechnology progress · 2021Article
- Strategies to Refine Gastric Stimulation and Pacing Protocols: Experimental and Modeling Approaches.Frontiers in neuroscience · 2021Review
- Model-based data analysis of individual human postprandial plasma bile acid responses indicates a major role for the gallbladder and intestine.Physiological reports · 2020Article
- Mechanistic modeling of gastrointestinal motility with integrated dissolution for simulating drug absorption.ADMET & DMPK · 2020Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several models of Gastric Emptying (GE) have been employed in the past to represent the rate of delivery of stomach contents to the duodenum and jejunum. These models have all used a deterministic form (algebraic equations or ordinary differential equations), considering GE as a continuous, smooth process in time. However, GE is known to occur as a sequence of spurts, irregular both in size and in timing. Hence, we formulate a simple stochastic process model, able to represent the irregular decrements of gastric contents after a meal. The model is calibrated on existing literature data and provides consistent predictions of the observed variability in the emptying trajectories. This approach may be useful in metabolic modeling, since it describes well and explains the apparently heterogeneous GE experimental results in situations where common gastric mechanics across subjects would be expected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.