ArticleAnnals of the American Thoracic Society2016
The Creation of a Biocontainment Unit at a Tertiary Care Hospital. The Johns Hopkins Medicine Experience.
Article in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- The role of pharmacists and pharmacy team members in the prevention, preparedness, response and recovery of outbreaks - a global rapid systematic review.BMC public health · 2026Pooled it
- Managing ICU surge during the COVID-19 crisis: rapid guidelines.Intensive care medicine · 2020Guideline
- Preparedness and Response Considerations for High-Consequence Infectious Disease.Emerging infectious diseases · 2025Review
- A narrative review of high-level isolation unit operational and infrastructure features.BMJ global health · 2023Review
- The Use of Temperature and Pressure Data Loggers to Validate the Steam Sterilization of Category A Clinical Waste.Applied biosafety : journal of the American Biological Safety Association · 2022Article
- Preparing for patients with high-consequence infectious diseases: Example of a high-level isolation unit.PloS one · 2022Article
- Modeling hospital energy and economic costs for COVID-19 infection control interventions.Energy and buildings · 2021Article
- Patient Trajectories Among Persons Hospitalized for COVID-19 : A Cohort Study.Annals of internal medicine · 2021Article
- How to rapidly design and operationalise PPE donning and doffing areas for a COVID-19 care facility: quality improvement initiative.BMJ open quality · 2020Article
- Design Strategies for Biocontainment Units to Reduce Risk During Doffing of High-level Personal Protective Equipment.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Impact of air-handling system exhaust failure on dissemination pattern of simulant pathogen particles in a clinical biocontainment unit.Indoor air · 2019Article
- High-Containment Pathogen Preparation in the Intensive Care Unit.Infectious disease clinics of North America · 2017Review
- Validation of Autoclave Protocols for Successful Decontamination of Category A Medical Waste Generated from Care of Patients with Serious Communicable Diseases.Journal of clinical microbiology · 2017Article
- Responding to the Global Threat of High-Consequence Pathogens: Protecting Health Care Workers and Caring for Patients.Annals of the American Thoracic Society · 2016Article
- Decision Making and Interventions During Interfacility Transport of High-Acuity Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.Air medical journalObservational
- Genomics in Patient Care and Workforce Decisions in High-Level Isolation Units: A Survey of Healthcare Workers.Health securityArticle
- Simulation of a Spontaneous Vaginal Delivery and Neonatal Resuscitation in a Biocontainment Unit.Health securityArticle
- A Critical Care Transport Program's Innovative Approach to Safety During the Coronavirus Disease 2019 Pandemic.Air medical journalArticle
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Authors and funding
31 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In response to the 2014-2015 Ebola virus disease outbreak in West Africa, Johns Hopkins Medicine created a biocontainment unit to care for patients infected with Ebola virus and other high-consequence pathogens. The unit team examined published literature and guidelines, visited two existing U.S. biocontainment units, and contacted national and international experts to inform the design of the physical structure and patient care activities of the unit. The resulting four-bed unit allows for unidirectional flow of providers and materials and has ample space for donning and doffing personal protective equipment. The air-handling system allows treatment of diseases spread by contact, droplet, or airborne routes of transmission. An onsite laboratory and an autoclave waste management system minimize the transport of infectious materials out of the unit. The unit is staffed by self-selected nurses, providers, and support staff with pediatric and adult capabilities. A telecommunications system allows other providers and family members to interact with patients and staff remotely. A full-time nurse educator is responsible for staff training, including quarterly exercises and competency assessment in the donning and doffing of personal protective equipment. The creation of the Johns Hopkins Biocontainment Unit required the highest level of multidisciplinary collaboration. When not used for clinical care and training, the unit will be a site for research and innovation in highly infectious diseases. The lessons learned from the design process can inform a new research agenda focused on the care of patients in a biocontainment environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.