Evidence map›Paper›PMID 27057545›Full record

ArticleBioMed research international2016

Motif-Based Text Mining of Microbial Metagenome Redundancy Profiling Data for Disease Classification.

Yin Wang, Rudong Li, Yuhua Zhou, Zongxin Ling, Xiaokui Guo, Lu Xie, Lei Liu

Abstract read
In one paragraph

Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yin WangShanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China; Shanghai Center for Bioinformation Technology, Shanghai 201203, China.
Rudong LiKey Lab of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0000-0002-8996-920X
Yuhua ZhouDepartment of Medical Microbiology and Parasitology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
Zongxin LingCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.
Xiaokui GuoDepartment of Medical Microbiology and Parasitology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
Lu XieShanghai Center for Bioinformation Technology, Shanghai 201203, China.
Lei LiuShanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China; Shanghai Center for Bioinformation Technology, Shanghai 201203, China.

Funding

Protective behavioral strategies and mental health: Reducing alcohol-related riskR21AA020104 · NIAAA · LOYOLA MARYMOUNT UNIVERSITY · PI LABRIE, JOSEPH W. · 2010 to 2011
$367k
NIAAA NIH HHS R21 AA020104
6 · The paper itself

Abstract

backgroundText data of 16S rRNA are informative for classifications of microbiota-associated diseases. However, the raw text data need to be systematically processed so that features for classification can be defined/extracted; moreover, the high-dimension feature spaces generated by the text data also pose an additional difficulty.

resultsHere we present a Phylogenetic Tree-Based Motif Finding algorithm (PMF) to analyze 16S rRNA text data. By integrating phylogenetic rules and other statistical indexes for classification, we can effectively reduce the dimension of the large feature spaces generated by the text datasets. Using the retrieved motifs in combination with common classification methods, we can discriminate different samples of both pneumonia and dental caries better than other existing methods.

conclusionsWe extend the phylogenetic approaches to perform supervised learning on microbiota text data to discriminate the pathological states for pneumonia and dental caries. The results have shown that PMF may enhance the efficiency and reliability in analyzing high-dimension text data.

Indexed as

AlgorithmsBacterial InfectionsCluster AnalysisData MiningDental CariesHumansMetagenomeMetagenomicsPhylogenyPneumoniaRNA, Ribosomal, 16SSupervised Machine LearningRNA, Ribosomal, 16S

Identifiers

PMID27057545
PMCPMC4769744

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LicenceCC BY
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.