Evidence map›Paper›PMID 27057436›Full record

ArticleOncoimmunology2016

Immunological markers and clinical outcome of advanced melanoma patients receiving ipilimumab plus fotemustine in the NIBIT-M1 study.

Cristina Maccalli, Diana Giannarelli, Filippo Capocefalo, Lorenzo Pilla, Ester Fonsatti, Anna Maria Di Giacomo, Giorgio Parmiani, Michele Maio

Open access · goldAbstract read
In one paragraph

Article in Oncoimmunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 31 citations in OpenAlex.

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  12. Immune signature profiling identified prognostic factors for gastric cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2019
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  16. Immunotherapy biomarkers 2016: overcoming the barriers.Journal for immunotherapy of cancer · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cristina MaccalliItalian Network for Biotherapy of Tumors-(NIBIT)-Laboratory, Siena, Italy; Medical Oncology and Immunotherapy, University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy; Unit of Immuno-biotherapy of Melanoma and Solid Tumors, San Raffaele Foundation Center, Milan, Italy.
Diana GiannarelliUnit of Statistics, Regina Elena National Cancer Institute , Rome, Italy.
Filippo CapocefaloUnit of Immuno-biotherapy of Melanoma and Solid Tumors, San Raffaele Foundation Center , Milan, Italy.
Lorenzo PillaMedical Oncology and Immunotherapy, University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy; Unit of Immuno-biotherapy of Melanoma and Solid Tumors, San Raffaele Foundation Center, Milan, Italy.
Ester FonsattiMedical Oncology and Immunotherapy, University Hospital of Siena, Istituto Toscano Tumori , Siena, Italy.
Anna Maria Di GiacomoMedical Oncology and Immunotherapy, University Hospital of Siena, Istituto Toscano Tumori , Siena, Italy.
Giorgio ParmianiItalian Network for Biotherapy of Tumors-(NIBIT)-Laboratory, Siena, Italy; Medical Oncology and Immunotherapy, University Hospital of Siena, Istituto Toscano Tumori, Siena, Italy; Unit of Immuno-biotherapy of Melanoma and Solid Tumors, San Raffaele Foundation Center, Milan, Italy.
Michele MaioMedical Oncology and Immunotherapy, University Hospital of Siena, Istituto Toscano Tumori , Siena, Italy.
University of Siena · ITNetwork Italiano Per la Bioterapia Dei Tumori · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical activity was observed in metastatic melanoma (MM) patients treated with ipilimumab (IPI) combined with fotemustine (FTM) in the phase II NIBIT-M1 study. Peripheral blood mononuclear cells (PBMCs) and serum were collected from MM patients at pre- and at weeks 12 and 24 post-treatment. A comprehensive phenotypic and functional immunomonitoring of circulating T cells, and the detection of soluble immunoregulatory molecules was carried out and correlated with clinical outcome. The frequency at baseline and along the treatment of circulating T central memory cells expressing activation/differentiation markers, such as CD3

Indexed as

Cytotoxic T-lymphocyte Antigen-4 (CTLA-4)MelanomaNKG2D ligandsT cell subsets

Identifiers

PMID27057436
PMCPMC4801454
OpenAlexW2194718048

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.