Evidence map›Paper›PMID 27057328›Full record

ArticleMaternal health, neonatology and perinatology2015

Global network for women's and children's health research: a system for low-resource areas to determine probable causes of stillbirth, neonatal, and maternal death.

Elizabeth M McClure, Carl L Bose, Ana Garces, Fabian Esamai, Shivaprasad S Goudar, Archana Patel, Elwyn Chomba, Omrana Pasha, Antoinette Tshefu, Bhalchandra S Kodkany and 13 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Maternal health, neonatology and perinatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03438110 (Project to Understand & Research Preterm Pregnancy Outcomes-South Asia), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
8.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03438110 completednot on this mapstarted 2018, after this paper: background citation

Project to Understand & Research Preterm Pregnancy Outcomes-South Asia (PURPOSe)

TypeobservationalSponsorRTI InternationalRan2018 to 2020Enrolled1,226ConditionsNeonatal Death, Stillbirth
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
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  10. Criteria for assigning cause of death for stillbirths and neonatal deaths in research studies in low-middle income countries.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 16 institutions in 6 countries.

Elizabeth M McClureRTI International, Durham, NC USA.
Carl L BoseUniversity of North Carolina at Chapel Hill, Chapel Hill, NC USA.
Ana GarcesFANCAP, Guatemala City, Guatemala.
Fabian EsamaiMoi University Medical Teaching Hospital, Eldoret, Kenya.
Shivaprasad S GoudarKLE University's JN Medical College, Belgaum, India.
Archana PatelLatta Medical Research Foundation, Indira Gandhi Medical School, Nagpur, India.
Elwyn ChombaUniversity of Zambia, Lusaka, Zambia.
Omrana PashaAga Khan University, Karachi, Pakistan.
Antoinette TshefuKinshasa School of Public Health, Kinshasa, Democratic Republic of the Congo.
Bhalchandra S KodkanyKLE University's JN Medical College, Belgaum, India.
Sarah SaleemAga Khan University, Karachi, Pakistan.
Waldemar A CarloUniversity of Alabama at Birmingham, Birmingham, AL USA.
Richard J DermanChristiana Health Care, Newark, DE USA.
Patricia L HibberdMassachusetts General Hospital, Boston, MA USA.
Edward A LiechtyIndiana University, Indianapolis, IN USA.
K Michael HambidgeUniversity of Colorado, Denver, CO USA.
Nancy F KrebsUniversity of Colorado, Denver, CO USA.
Melissa BausermanUNC Chapel Hill, Chapel Hill, NC USA.
Marion Koso-ThomasPerinatology and Pregnancy Branch, NICHD, Bethesda, MD USA.
Janet MooreRTI International, Durham, NC USA.
Dennis D WallaceRTI International, Durham, NC USA.
Alan H JobeCincinnati Children's Hospital, Cincinnati, OH USA.
Robert L GoldenbergColumbia University Medical Center, New York, NY USA.
RTI International · USAga Khan University · PKKLE University · INUniversity of Colorado Denver · USUniversity of North Carolina at Chapel Hill · USBoston University · USChristiana Care Health System · USCincinnati Children's Hospital Medical Center · USColumbia University Irving Medical Center · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USIndiana University – Purdue University Indianapolis · USLata Medical Research Foundation · INMinistry of Public Health · CDMoi University · KEUniversity of Alabama at Birmingham · USUniversity of Zambia · ZM

Funding

Zika in Pregnancy Supplemental Funding requestU01HD040636 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI MCCLURE, ELIZABETH M · 2001 to 2017
$37.5M
UAB/AKU Global Network Research UnitU01HD040607 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GOLDENBERG, ROBERT L · 2001 to 2012
$8.5M
Complementary feeding: a Global Network cluster randomized controlled trialU01HD040657 · NICHD · UNIVERSITY OF COLORADO DENVER · PI HAMBIDGE, K MICHAEL · 2001 to 2012
$8.1M
UMKC-JNMC Global Network for Women's and Children's Health Research UnitU01HD042372 · NICHD · UNIVERSITY OF MISSOURI KANSAS CITY · PI DERMAN, RICHARD J · 2001 to 2012
$6.9M
Neonatal Resuscitation in Developing CountriesU01HD043464 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARLO FONT, WALDEMAR A. · 2003 to 2012
$6.6M
Evidence-Based Global Health Interventions for Mothers and Children, ArgentinaU01HD040477 · NICHD · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI BUEKENS, PIERRE · 2001 to 2013
$5.6M
Improving Quality of Care for the Treatment of Childhood PneumoniaU01HD058322 · NICHD · TUFTS UNIVERSITY BOSTON · PI HIBBERD, PATRICIA L · 2008 to 2012
$4.0M
CCHS-JNMC Global Network for Women's & Children's Health Research UnitU10HD076457 · NICHD · THOMAS JEFFERSON UNIVERSITY · PI DERMAN, RICHARD J · 2013 to 2017
$3.7M
Global Network for Women's and Children's HealthU01HD058326 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI LIECHTY, EDWARD A. · 2008 to 2012
$3.6M
Maternal and Child Health Benefits from Reducing Household Air PollutionU10HD078439 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI HIBBERD, PATRICIA L · 2013 to 2017
$3.1M
NICHD NIH HHS U01 HD040477NICHD NIH HHS U01 HD040607NICHD NIH HHS U01 HD040636NICHD NIH HHS U01 HD040657NICHD NIH HHS U01 HD042372NICHD NIH HHS U01 HD043464NICHD NIH HHS U01 HD058322NICHD NIH HHS U01 HD058326NICHD NIH HHS U10 HD076457NICHD NIH HHS U10 HD078439
6 · The paper itself

Abstract

backgroundDetermining cause of death is needed to develop strategies to reduce maternal death, stillbirth, and newborn death, especially for low-resource settings where 98% of deaths occur. Most existing classification systems are designed for high income settings where extensive testing is available. Verbal autopsy or audits, developed as an alternative, are time-intensive and not generally feasible for population-based evaluation. Furthermore, because most classification is user-dependent, reliability of classification varies over time and across settings. Thus, we sought to develop classification systems for maternal, fetal and newborn mortality based on minimal data to produce reliable cause-of-death estimates for low-resource settings.

resultsIn six low-resource countries (India, Pakistan, Guatemala, DRC, Zambia and Kenya), we evaluated data which are collected routinely at antenatal care and delivery and could be obtained with interview, observation, or basic equipment from the mother, lay-health provider or family to inform causes of death. Using these basic data collected in a standard way, we then developed an algorithm to assign cause of death that could be computer-programmed. Causes of death for maternal (trauma, abortion, hemorrhage, infection and hypertensive disease of pregnancy), stillbirth (birth trauma, congenital anomaly, infection, asphyxia, complications of preterm birth) and neonatal death (congenital anomaly, infection, asphyxia, complications of preterm birth) are based on existing cause of death classifications, and compatible with the World Health Organization International Classification of Disease system.

conclusionsOur system to assign cause of maternal, fetal and neonatal death uses basic data from family or lay-health providers to assign cause of death by an algorithm to eliminate a source of inconsistency and bias. The major strengths are consistency, transparency, and comparability across time or regions with minimal burden on the healthcare system. This system will be an important contribution to determining cause of death in low-resource settings.

Indexed as

Cause of death classificationLow-income CountriesMaternal mortalityNeonatal mortalityStillbirth

Identifiers

PMID27057328
PMCPMC4823684
OpenAlexW2137496447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.