ArticleStem cells translational medicine2016
Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs.
Article in Stem cells translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Genome-wide microRNA profiles identify miR-107 as a top miRNA associating with expression of the CYP3As and other drug metabolizing cytochrome P450 enzymes in the liver.Frontiers in pharmacology · 2022Article
- Mapping the miRNA-mRNA Interactome in Human Hepatocytes and Identification of Functional mirSNPs in Pharmacogenes.Clinical pharmacology and therapeutics · 2021Article
- Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells.EXCLI journal · 2020Article
- iPSC-Derived Hepatocytes as a Platform for Disease Modeling and Drug Discovery.Frontiers in medicine · 2019Review
- Semi-automated Production of Hepatocyte Like Cells from Pluripotent Stem Cells.Journal of visualized experiments : JoVE · 2018Article
- Liver cell therapy: is this the end of the beginning?Cellular and molecular life sciences : CMLS · 2018Review
- Ethyl pyruvate attenuates acetaminophen-induced liver injury and prevents cellular injury induced byHeliyon · 2018Article
- Current Perspectives Regarding Stem Cell-Based Therapy for Liver Cirrhosis.Canadian journal of gastroenterology & hepatology · 2018Review
- Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety.The AAPS journal · 2017Review
- Modelling foetal exposure to maternal smoking using hepatoblasts from pluripotent stem cells.Archives of toxicology · 2017Article
- Lipidomic profiling of patient-specific iPSC-derived hepatocyte-like cells.Disease models & mechanisms · 2017Article
- Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis.International journal of molecular sciences · 2017Review
- A Drug Screen using Human iPSC-Derived Hepatocyte-like Cells Reveals Cardiac Glycosides as a Potential Treatment for Hypercholesterolemia.Cell stem cell · 2017Article
- Defined and Scalable Generation of Hepatocyte-like Cells from Human Pluripotent Stem Cells.Journal of visualized experiments : JoVE · 2017Article
- Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells.Stem cells and development · 2016Article
- Concise Review: Advances in Generating Hepatocytes from Pluripotent Stem Cells for Translational Medicine.Stem cells (Dayton, Ohio) · 2016Review
- Pluripotent stem cell derived hepatocytes: using materials to define cellular differentiation and tissue engineering.Journal of materials chemistry. B · 2016Review
- Noncoding RNAs as therapeutics for acetaminophen-induced liver injury.Stem cell investigation · 2016Article
- miRNA-324, a potential therapeutic target for paracetamol-induced liver injury.Stem cell investigation · 2016Article
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6 authors at 2 institutions in 1 country.
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Abstract
unlabelledThe liver performs multiple functions within the human body. It is composed of numerous cell types, which play important roles in organ physiology. Our study centers on the major metabolic cell type of the liver, the hepatocyte, and its susceptibility to damage during drug overdose. In these studies, hepatocytes were generated from a renewable and genetically defined resource. In vitro-derived hepatocytes were extensively profiled and exposed to varying levels of paracetamol and plasma isolated from liver-failure patients, with a view to identifying noncoding microRNAs that could reduce drug- or serum-induced hepatotoxicity. We identified a novel anti-microRNA, which reduced paracetamol-induced hepatotoxicity and glutathione depletion. Additionally, we identified a prosurvival role for anti-microRNA-324 following exposure to plasma collected from liver failure patients. We believe that these studies represent an important advance for the field, demonstrating the power of stem cell-derived systems to model human biology "in a dish" and identify novel noncoding microRNAs, which could be translated to the clinic in the future. SIGNIFICANCE: The liver performs vital functions within the human body and is composed of numerous cell types. The major metabolic cell type of the liver, the hepatocyte, is susceptible to damage during drug overdose. In these studies, hepatocytes were generated from a renewable resource and exposed to varying levels of paracetamol, with a view to identifying interventions that could reduce or attenuate drug-induced liver toxicity. A novel noncoding RNA that reduced paracetamol-induced hepatocyte toxicity was identified. These findings may represent an important advance for the field.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.