Trial reportLasers in medical science2016
Effects of low-level laser therapy on bone regeneration of the midpalatal suture after rapid maxillary expansion.
Trial report in Lasers in medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Effectiveness of adjunctive interventions in patients undergoing rapid maxillary expansion: An umbrella review.The Journal of international medical research · 2026Pooled it
- Orthodontic treatment for posterior crossbites.The Cochrane database of systematic reviews · 2021Pooled it
- Comprehensive Effects of Photobiomodulation Therapy as an Adjunct to Post-orthodontic Treatment Care: A Systematic Review.Oral health & preventive dentistry · 2021Pooled it
- Effects of laser therapy on patients who underwent rapid maxillary expansion; a systematic review.Lasers in medical science · 2018Pooled it
- Evaluating the impact of various predictors on rapid maxillary expansion (RME) success.Clinical oral investigations · 2025Trial
- Heterologous Fibrin Biopolymer as a Key Scaffold for Bone Regeneration: Synergistic Effects with Photobiomodulation and Membrane Therapy.Gels (Basel, Switzerland) · 2026Article
- Benefits and Effects of Laser-Based Techniques in Complementary Maxillary Expansion: A Narrative Review.Cureus · 2024Review
- Effectiveness of low-level laser therapy in facilitating maxillary expansion using bone-borne hyrax expander: A randomized clinical trial.Korean journal of orthodontics · 2022Article
- Effect of Simvastatin and Low-Level Laser Therapy on Sutural Bone Formation After Expansion in Rats: Biomechanical, Computed Tomography and Immunohistochemical Assessment.Journal of lasers in medical sciences · 2022Article
- Effect of Puerarin on Osteogenic Differentiation in vitro and on New Bone Formation in vivo.Drug design, development and therapy · 2022Article
- Effect of low-level laser therapy on condylar growth in children treated with functional appliance: a preliminary study.Lasers in dental science · 2022Article
- Effect of Low-Level Laser Therapy on Bone Formation in Rapid Palatal Expansion: A Systematic Review.Journal of lasers in medical sciences · 2022Review
- Do adjunctive interventions in patients undergoing rapid maxillary expansion increase the treatment effectiveness?The Angle orthodontist · 2021Article
- Article
- Benefits of Using Low-level Laser Therapy in the Rapid Maxillary Expansion: A Systematic Review.International journal of clinical pediatric dentistry · 2021Review
- Effect of mesenchymal stem cells injection and low-level laser therapy on bone formation after rapid maxillary expansion: an animal study.American journal of stem cells · 2020Article
- Article
- The influence of LLLT applied on applied on calvarial defect in rats under effect of cigarette smoke.Journal of applied oral science : revista FOB · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study evaluated the effect of low-level laser therapy (LLLT) on bone regeneration at the midpalatal suture (MPS) after rapid maxillary expansion (RME), using cone beam computed tomography. Fourteen 8-14-year-old patients with transverse maxillary deficiency underwent RME with a Hyrax-type expander activated with one full turn after installation and two half turn daily activations until achieving overcorrection. Patients were randomly assigned to either a control group (RME alone, n = 4) or an experimental group (n = 10) in which RME was followed by 12 LLLT sessions (GaAlAs, p = 70 mW, λ = 780 nm, Ø = 0.04 cm(2)). Two tomographic images of the MPS were obtained-T0, after disjunction and T1, after 4 months. Bone regeneration was evaluated by measuring the optical density (OD) on the tomographic images using InVivo Dental 5.0 software. Data were analyzed by the paired Student's t test (α = 0.05 %). A statistically significant difference between T0 and T1 OD values was observed in the laser-treated group (p = 0.00), but this difference was not significant in the control group (p = 0.20). Intergroup comparison of OD values at T1 revealed higher OD in the laser-treated group (p = 0.05). In conclusion, LLLT had a positive influence on bone regeneration of the midpalatal suture by accelerating the repair process.
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