Evidence map›Paper›PMID 27056686›Full record

Trial reportKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2017

Choice of intra-articular injection in treatment of knee osteoarthritis: platelet-rich plasma, hyaluronic acid or ozone options.

Tahir Mutlu Duymus, Serhat Mutlu, Bahar Dernek, Baran Komur, Suavi Aydogmus, Fatma Nur Kesiktas

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07662512 (Is Intra-articular Injection of High-concentration Ozone), which is not on this map. Cited by 120 papers, 26 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 26 pooled it
27.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07662512 nacompletednot on this mapstarted 2023, after this paper: background citation

Is Intra-articular Injection of High-concentration Ozone (O2-O3) More Effective in Treating Knee Osteoarthritis?: A Multicenter Clinical Trial

TypeinterventionalSponsorSakarya UniversityRan2023 to 2024Enrolled159ConditionsKnee Osteoarthristis, GonarthrosisArmsozone injection
3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 26 syntheses or guidelines pooled it, 291 citations in OpenAlex.

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  8. Intra-articular injections of ozone versus hyaluronic acid for knee osteoarthritis: a level I meta-analysis.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024
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60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Tahir Mutlu DuymusDepartment of Orthopaedics, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Atakent Mh., 1. Cd, 34303, Küçükçekmece, Istanbul, Turkey. dr.tahirmutlu@gmail.com.
Serhat MutluDepartment of Orthopaedics, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Atakent Mh., 1. Cd, 34303, Küçükçekmece, Istanbul, Turkey.
Bahar DernekDepartment of Physical Medicine and Rehabilitation, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Atakent Mh., 1. Cd, 34303, Küçükçekmece, Istanbul, Turkey.
Baran KomurDepartment of Orthopaedics, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Atakent Mh., 1. Cd, 34303, Küçükçekmece, Istanbul, Turkey.
Suavi AydogmusDepartment of Orthopedic Surgery and Traumatology, Haydarpaşa Numune Education and Research Hospital, 34668, Üsküdar, Istanbul, Turkey.
Fatma Nur KesiktasPhysical Medicine and Rehabilitation Education and Research Hospital, Kocasinan Merkez Mah. Karadeniz Cad.No 48, 34147, Bahcelievler, Istanbul, Turkey.
İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi · TRHaydarpaşa Numune Eğitim ve Araştırma Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study was performed to compare the efficacy of treatment in three groups of patients with knee osteoarthritis (OA) given an intra-articular injection of platelet-rich plasma (PRP), hyaluronic acid (HA) or ozone gas.

methodsA total of 102 patients with mild-moderate and moderate knee OA who presented at the polyclinic with at least a 1-year history of knee pain and VAS score ≥4 were randomly separated into three groups. Group 1 (PRP group) received intra-articular injection of PRP × 2 doses, Group 2 (HA group) received a single dose of HA, and Group 3 (Ozone group) received ozone × four doses. Weight-bearing anteroposterior-lateral and Merchant's radiographs of both knees were evaluated. WOMAC and VAS scores were applied to all patients on first presentation and at 1, 3, 6 and 12 months.

resultsAt the end of the 1st month after injection, significant improvements were seen in all groups. In the 3rd month, the improvements in WOMAC and VAS scores were similar in Groups 1 and 2, while those in Group 3 were lower (p < 0.001). At the 6th month, while the clinical efficacies of PRP and HA were similar and continued, the clinical effect of ozone had disappeared (p < 0.001). At the end of the 12th month, PRP was determined to be both statistically and clinically superior to HA (p < 0.001).

conclusionIn the treatment of mild-moderate knee OA, PRP was more successful than HA and ozone injections, as the application alone was sufficient to provide at least 12 months of pain-free daily living activities. LEVEL OF EVIDENCE: Therapeutic study, Level I.

Indexed as

Choice BehaviorInjections, Intra-ArticularPlatelet-Rich PlasmaAgedFemaleHumansHyaluronic AcidKnee JointMaleMiddle AgedOsteoarthritis, KneeOzonePainPain MeasurementRadiographyTreatment OutcomeHyaluronic AcidOzoneHyaluronic acidIntra-articular injection optionsKnee osteoarthritisOzonePlatelet-rich plasma

Identifiers

PMID27056686
OpenAlexW2327421967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.