ReviewCellular and molecular life sciences : CMLS2016
Developmental checkpoints guarded by regulated necrosis.
Review in Cellular and molecular life sciences : CMLS, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Cooperation of TRADD- and RIPK1-dependent cell death pathways in maintaining intestinal homeostasis.Nature communications · 2025Article
- Evidence for developmental vascular-associated necroptosis and its contribution to venous-lymphatic endothelial differentiation.Frontiers in cell and developmental biology · 2023Article
- RIPK3 modulates growth factor receptor expression in endothelial cells to support angiogenesis.Angiogenesis · 2021Article
- The potential role of necroptosis in clinical diseases (Review).International journal of molecular medicine · 2021Review
- Necroptosis restricts influenza A virus as a stand-alone cell death mechanism.The Journal of experimental medicine · 2020Article
- The NuRD chromatin-remodeling complex enzyme CHD4 prevents hypoxia-induced endothelial Ripk3 transcription and murine embryonic vascular rupture.Cell death and differentiation · 2020Article
- An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling.F1000Research · 2020Review
- Cell Death in the Kidney.International journal of molecular sciences · 2019Review
- The molecular machinery of regulated cell death.Cell research · 2019Review
- Regulation of alveolar macrophage death in acute lung inflammation.Respiratory research · 2018Review
- The Contribution of Necroptosis in Neurodegenerative Diseases.Neurochemical research · 2017Review
- Caspase-8: regulating life and death.Immunological reviews · 2017Review
- RIPK3-driven cell death during virus infections.Immunological reviews · 2017Review
- Programmed cell death as a defence against infection.Nature reviews. Immunology · 2017Review
- Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.Trends in pharmacological sciences · 2017Review
- Lack of FADD in Tie-2 expressing cells causes RIPK3-mediated embryonic lethality.Cell death & disease · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The process of embryonic development is highly regulated through the symbiotic control of differentiation and programmed cell death pathways, which together sculpt tissues and organs. The importance of programmed necrotic (RIPK-dependent necroptosis) cell death during development has recently been recognized as important and has largely been characterized using genetically engineered animals. Suppression of necroptosis appears to be essential for murine development and occurs at three distinct checkpoints, E10.5, E16.5, and P1. These distinct time points have helped delineate the molecular pathways and regulation of necroptosis. The embryonic lethality at E10.5 seen in knockouts of caspase-8, FADD, or FLIP (cflar), components of the extrinsic apoptosis pathway, resulted in pallid embryos that did not exhibit the expected cellular expansions. This was the first suggestion that these factors play an important role in the inhibition of necroptotic cell death. The embryonic lethality at E16.5 highlighted the importance of TNF engaging necroptosis in vivo, since elimination of TNFR1 from casp8 (-/-), fadd (-/-), or cflar (-/-), ripk3 (-/-) embryos delayed embryonic lethality from E10.5 until E16.5. The P1 checkpoint demonstrates the dual role of RIPK1 in both the induction and inhibition of necroptosis, depending on the upstream signal. This review summarizes the role of necroptosis in development and the genetic evidence that helped detail the molecular mechanisms of this novel pathway of programmed cell death.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.