Evidence map›Paper›PMID 27056268›Full record

Trial reportThe Journal of allergy and clinical immunology2016

Pioglitazone as a novel therapeutic approach in chronic granulomatous disease.

Maddalena Migliavacca, Andrea Assanelli, Francesca Ferrua, Maria Pia Cicalese, Alessandra Biffi, Marta Frittoli, Paolo Silvani, Giovanna Chidini, Edoardo Calderini, Anna Mandelli and 7 more

Registry-linked trialOpen access · hybridAbstract readCase ReportsClinical TrialLetter
In one paragraph

Trial report in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03080480 (Efficacy and Safety of Pioglitazone Therapy for Chronic Granulomatous Disease Patients With Severe Infection.), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03080480 phase1 / phase2terminatednot on this mapstarted 2017, after this paper: background citation

Efficacy and Safety of Pioglitazone Therapy for Chronic Granulomatous Disease Patients With Severe Infection.

TypeinterventionalSponsorChildren's Hospital of Fudan UniversityRan2017 to 2019Enrolled3ConditionsChronic Granulomatous DiseaseArmsPioglitazone
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. The combined pioglitazone and topiramate therapy for management of pediatric patients with severe MASLD.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2024
    Article
  2. Review
  3. Article
  4. Chronic Granulomatous Disease: a Comprehensive Review.Clinical reviews in allergy & immunology · 2021
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. An Update on the Use of Immunomodulators in Primary Immunodeficiencies.Clinical reviews in allergy & immunology · 2017
    Review
  15. NADPH Oxidase Deficiency: A Multisystem Approach.Oxidative medicine and cellular longevity · 2017
    Review
  16. PPARPPAR research · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Maddalena MigliavaccaSan Raffaele Telethon Institute for Gene Therapy (TIGET), Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy.
Andrea AssanelliHematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy.
Francesca FerruaSan Raffaele Telethon Institute for Gene Therapy (TIGET), Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy.
Maria Pia CicaleseSan Raffaele Telethon Institute for Gene Therapy (TIGET), Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy.
Alessandra BiffiSan Raffaele Telethon Institute for Gene Therapy (TIGET), Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy.
Marta FrittoliSan Raffaele Telethon Institute for Gene Therapy (TIGET), Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy.
Paolo SilvaniDepartment of Anesthesia and Critical Care, San Raffaele Hospital, Milan, Italy.
Giovanna ChidiniPediatric Intensive Care Unit, Department of Anesthesia and Critical Care, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Edoardo CalderiniPediatric Intensive Care Unit, Department of Anesthesia and Critical Care, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Anna MandelliPediatric Anesthesia and Intensive Care, Children Hospital "V.Buzzi", Milan, Italy.
Anna CamporesiPediatric Anesthesia and Intensive Care, Children Hospital "V.Buzzi", Milan, Italy.
Raffaella MilaniCytometry Laboratory, San Raffaele Scientific Institute, Milan, Italy.
Giada FarinelliSan Raffaele Telethon Institute for Gene Therapy (TIGET), San Raffaele Scientific Institute, Milan, Italy.
Roberto NicolettiDepartment of Radiology, San Raffaele Scientific Institute, Milan, Italy.
Fabio CiceriHematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy.
Alessandro AiutiSan Raffaele Telethon Institute for Gene Therapy (TIGET), Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy. Electronic address: a.aiuti@hsr.it.
Maria Ester BernardoSan Raffaele Telethon Institute for Gene Therapy (TIGET), Pediatric Immunohematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milan, Italy.
The San Raffaele Telethon Institute for Gene Therapy · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITOspedale dei Bambini Vittore Buzzi · ITSan Raffaele University of Rome · ITVita-Salute San Raffaele University · IT

Funding

Telethon TGTGSK06
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Granulomatous Disease, ChronicHumansInfantMalePioglitazoneThiazolidinedionesPioglitazoneThiazolidinediones

Identifiers

PMID27056268
PMCPMC4889778
OpenAlexW2320592725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.