ReviewChronic respiratory disease2016
Molecular and biological pathways of skeletal muscle dysfunction in chronic obstructive pulmonary disease.
Review in Chronic respiratory disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04449419 (Mitoquines as Prognostic Factors of Exacerbations and Hospital Admission in COPD Patients.), which is not on this map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mitoquines as Prognostic Factors of Exacerbations and Hospital Admission in COPD Patients.
Who cites it
40 citing papers in PubMed, 81 citations in OpenAlex.
- Evaluation of the possible effect of inspiratory muscle training on inflammation markers and oxidative stress in childhood asthma.European journal of pediatrics · 2023Trial
- Effect of physical training on cytokine expression in CD4+ T lymphocytes in subjects with stable COPD.Therapeutic advances in respiratory diseaseTrial
- Low Body Mass Index Is Associated with a Long-Term Decline in Accelerometer-Measured Physical Activity in Patients with COPD: An Exploratory Analysis of Participants Co-Enrolled in Two Prospective Cohort Studies.Journal of clinical medicine · 2026Article
- Efficacy of Liuzijue in Improving Respiratory Muscle Dysfunction in Chronic Obstructive Pulmonary Disease: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2026Article
- Review
- Molecular and Structural Changes, and Skeletal Muscle Strength and Endurance in Chronic Obstructive Pulmonary Disease and Interstitial Lung Disease: Practical Applications of Assessment and Management.Bioengineering (Basel, Switzerland) · 2026Review
- Sex-Specific Plasma Metabolomic Signatures in COPD Reveal Creatine, Purine/Urate, and Bile-Acid Axes.Metabolites · 2026Article
- The lung-muscle axis in COPD: a conceptual framework integrating evidence, mechanisms, and therapeutic perspectives.Frontiers in immunology · 2026Review
- Review
- Probable respiratory sarcopenia and 9-year mortality in community-dwelling older adults: the first longitudinal evidence from the CHARLS.Scientific reports · 2025Article
- Nrf2 pathway potentially confers protection against cigarette smoke-induced sarcopenia in a mouse model.European journal of medical research · 2025Article
- Myostatin/Smad2/Smad3 pathway define a differential clinical phenotype in COPD-associated sarcopenia.ERJ open research · 2025Article
- Shear wave elastography, as a feasible tool, can be used to reflect the lower limb dysfunction in patients with chronic obstructive pulmonary disease?Scientific reports · 2025Article
- Influence of probable respiratory sarcopenia on chronic lung diseases: a population-based cohort study of community-dwelling Chinese older adults.Frontiers in medicine · 2025Article
- Muscle-enriched microRNA-486-mediated regulation of muscular atrophy and exercise.Journal of physiology and biochemistry · 2024Review
- Pulmonary Rehabilitation: Mechanisms of Functional Loss and Benefits of Exercise.Respiratory care · 2024Review
- Qualitative interviews of patients with COPD and muscle weakness enrolled in a clinical trial evaluating a new anabolic treatment: patient perspectives of disease experience, trial participation and outcome assessments.Journal of patient-reported outcomes · 2024Article
- Cigarette smoking inhibits myoblast regeneration by promoting proteasomal degradation of NPAT protein and hindering cell cycle progression.Current research in toxicology · 2024Article
- Cellular interplay in skeletal muscle regeneration and wasting: insights from animal models.Journal of cachexia, sarcopenia and muscle · 2023Review
- Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic obstructive pulmonary disease (COPD) will be a major leading cause of death worldwide in the near future. Weakness and atrophy of the quadriceps are associated with a significantly poorer prognosis and increased mortality in COPD. Despite that skeletal muscle dysfunction may affect both respiratory and limb muscle groups in COPD, the latter are frequently more severely affected. Therefore, muscle dysfunction in COPD is a common systemic manifestation that should be evaluated on routine basis in clinical settings. In the present review, several aspects of COPD muscle dysfunction are being reviewed, with special emphasis on the underlying biological mechanisms. Figures on the prevalence of COPD muscle dysfunction and the most relevant etiologic contributors are also provided. Despite that ongoing research will shed light into the contribution of additional mechanisms to COPD muscle dysfunction, current knowledge points toward the involvement of a wide spectrum of cellular and molecular events that are differentially expressed in respiratory and limb muscles. Such mechanisms are thoroughly described in the article. The contribution of epigenetic events on COPD muscle dysfunction is also reviewed. We conclude that in view of the latest discoveries, from now, on new avenues of research should be designed to specifically target cellular mechanisms and pathways that impair muscle mass and function in COPD using pharmacological strategies and/or exercise training modalities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.