ArticleEnvironmental science and pollution research international2016
The influence of Omega3 fatty acids supplementation against aluminum-induced toxicity in male albino rats.
Article in Environmental science and pollution research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 18 citations in OpenAlex.
- Nutraceuticals: A strategy to mitigate neurotoxicity.Advances in neurotoxicology · 2026Article
- Article
- Testicular tissue response following a 90-day subchronic exposure to HTP aerosols and cigarette smoke in rats.Toxicology research · 2023Article
- Antioxidant activity and protective effect of bee bread (honey and pollen) in aluminum-induced anemia, elevation of inflammatory makers and hepato-renal toxicity.Journal of food science and technology · 2017Article
- Exogenous phosphatidylcholine supplementation retrieve aluminum-induced toxicity in male albino rats.Environmental science and pollution research international · 2017Article
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
This study evaluated the protective and antioxidant potential of Omega3 fatty acids (FAs) against aluminum intoxicated male albino rats. Twenty-four male albino rats were divided into four equal groups: group I served as control; group II (Omega3-treated) received Omega3 FAs 1000 mg/kg bwt/day orally; group III (aluminum-treated) received aluminum chloride 100 mg/kg bwt/day orally and group IV (aluminum + Omega3-treated) received aluminum chloride 100 mg/kg bwt/day and Omega3 FAs 1000 mg/kg bwt/day orally. Treatments lasted for 4 weeks. Results indicate that administration of aluminum chloride showed non-significant changes in serum alanine aminotransferase, urea, and creatinine levels, a significant increase in serum aspartate aminotransferase and malondialdehyde as well as a significant reduction in serum-reduced glutathione levels. Aluminum treatment induced histopathological alterations in the liver, kidney, brain, testes, and epididymis. Omega3 FAs supplementation improved the serum parameters, enhanced endogenous antioxidant status, reduced lipid peroxidation, and ameliorated the intensity of the histopathological lesions. These findings reveal that Omega3 FAs supplementation can lighten the toxic effects of aluminum through their antioxidant and free radical-scavenging effects.
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