Observational studyEuropean journal of nutrition2017
Long-term association between the dietary inflammatory index and cognitive functioning: findings from the SU.VI.MAX study.
Observational study in European journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00272428 (The SU.VI.MAX Study. A Randomized, Placebo-controlled Prevention Trial of the Health Effects of Antioxidant Vitamins and Minerals.), which is not on this map. Cited by 51 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The SU.VI.MAX Study. A Randomized, Placebo-controlled Prevention Trial of the Health Effects of Antioxidant Vitamins and Minerals.
Who cites it
51 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Dietary patterns in middle age: effects on concurrent neurocognition and risk of age-related cognitive decline.Nutrition reviews · 2022Pooled it
- Association between dietary inflammatory index and cognitive impairment: A meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Pooled it
- Pooled it
- The effects of the Multicultural Healthy Diet on cognitive decline and Alzheimer's disease risk: a phase II randomized controlled trial in middle-aged adults.The American journal of clinical nutrition · 2025Trial
- The Inflammatory Potential of the Diet at Midlife Is Associated with Later Healthy Aging in French Adults.The Journal of nutrition · 2018Trial
- Association between dietary inflammatory potential and cognitive performance in children.European journal of nutrition · 2026Article
- Dietary inflammatory potential, systemic inflammation, and cognitive function in healthy adults in Saudi Arabia.Frontiers in nutrition · 2026Article
- Longitudinal Association of Inflammatory Diets on Cognition in Older Adults: Insights from the Oral-Gut-Brain Axis.Journal of the American Geriatrics Society · 2025Article
- Imbalanced nutrition and increased dietary inflammatory index in children with autism spectrum disorder: associations with neurodevelopmental disorders.Frontiers in nutrition · 2025Article
- Association between dietary inflammatory index score and incident dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The Relationship of Certain Diseases and Dietary Inflammatory Index in Older Adults: A Narrative Review.Current nutrition reports · 2024Review
- Anti-Inflammatory Diet and Dementia in Older Adults With Cardiometabolic Diseases.JAMA network open · 2024Article
- Article
- Effect of dairy consumption on cognition in older adults: A population-based cohort study.The journal of nutrition, health & aging · 2024Article
- The Association of Dietary Inflammatory Index and Cognitive Function in Iranian Elders.Recent advances in food, nutrition & agriculture · 2024Article
- Dietary inflammatory index is associated with Vitamin D in CKD patients.International urology and nephrology · 2024Article
- Dietary Inflammatory Index and Cognitive Function: Findings from a Cross-Sectional Study in Obese Chinese Township Population from 45 to 75 Years.Journal of inflammation research · 2024Article
- Plasma proteins related to inflammatory diet predict future cognitive impairment.Molecular psychiatry · 2023Article
- Telomere and mitochondria mediated the association between dietary inflammatory index and mild cognitive impairment: A prospective cohort study.Immunity & ageing : I & A · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
purposeInflammation is a ubiquitous underlying mechanism of the links between diet and cognitive functioning. No study has yet evaluated the overall inflammatory potential of the diet, using the dietary inflammatory index (DII), in relation to cognitive functioning. In a French cohort of middle-aged adults, we evaluated the association between the DII, assessed in midlife, and cognitive performance evaluated 13 years later.
methodsThe DII is a literature-derived dietary index developed to determine the inflammatory potential of diet. The DII was estimated at baseline (1994-1996) among 3080 subjects of the SU.VI.MAX (supplementation with antioxidant vitamins and minerals) cohort. Cognitive performance was assessed in 2007-2009 via a battery of standardized neuropsychological tests. Principal component analysis was performed to extract a summary score of cognitive performance. Multivariable-adjusted linear regression analyses were performed to provide regression coefficients and 95 % confidence intervals (95 % CI).
resultsIn a multivariate model, a strong inverse association was observed between a higher DII (reflecting a more inflammatory diet) and overall cognitive functioning (mean difference Q4 vs. Q1 = -1.76; 95 % CI = -2.81, -0.72, P for trend =0.002). With regard to specific cognitive domains, similar associations were observed with scores reflecting verbal memory, but not executive functioning.
conclusionThis study suggests that a pro-inflammatory diet at midlife might be associated with subsequent lower cognitive functioning. A diet exhibiting anti-inflammatory properties may help to maintain cognitive health during aging. CLINICAL
trial registrationClinicaltrials.gov (number NCT00272428).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.