Evidence map›Paper›PMID 27055847›Full record

SynthesisClinical oral investigations2016

Association between diabetes and the prevalence of radiolucent periapical lesions in root-filled teeth: systematic review and meta-analysis.

Juan J Segura-Egea, Jenifer Martín-González, Daniel Cabanillas-Balsera, Ashraf F Fouad, Eugenio Velasco-Ortega, José López-López

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 118 citations in OpenAlex.

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  12. Endodontic Inflammatory Disease: Systemic Consequences.Advances in experimental medicine and biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Juan J Segura-EgeaEndodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, Seville, Spain. segurajj@us.es.ORCID http://orcid.org/0000-0002-0427-9059
Jenifer Martín-GonzálezEndodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, Seville, Spain.
Daniel Cabanillas-BalseraEndodontic Section, Department of Stomatology, School of Dentistry, University of Sevilla, Seville, Spain.
Ashraf F FouadDepartment of Endodontics, University of North Carolina, Chapel Hill, USA.
Eugenio Velasco-OrtegaComprehensive Dentistry, Department of Stomatology, School of Dentistry, University of Sevilla, Seville, Spain.
José López-LópezOral Medicine, Department of Odontostomatology, School of Dentistry, University of Barcelona, Barcelona, Spain.
Universidad de Sevilla · ESUniversitat de Barcelona · ESUniversity of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe question of whether diabetes mellitus can influence the outcome of root canal treatment (RCT) remains unclear. The aim of this systematic review and meta-analysis was to analyze scientific available evidence on the association between diabetes and the presence of radiolucent periapical lesions (RPLs) in root-filled teeth (RFT).

methodsThe review question was as follows: in adult patients who had endodontically treated teeth, does the absence or presence of diabetes result in an increase in the prevalence of RPL associated to RFT? A systematic MEDLINE/PubMed, Wiley Online Database, Web of Science, and Scopus search was conducted using the following MeSH and keywords: Diabetes Mellitus OR Diabetes OR Diabetic OR Hyperglycemia, AND Endodontics, Periapical Periodontitis, Periapical Diseases, Apical Periodontitis, Periradicular Lesion, Periapical Radiolucency, Radiolucent Periapical Lesion, Root Canal Treatment, Root Canal Preparation, Root Canal Therapy, Root Filled Teeth, Endodontically Treated Teeth. Seven studies reporting data on the prevalence of RPL associated to RFT both in diabetic and control subjects were included.

resultsAfter the study selection, seven epidemiological studies fulfilled the inclusion criteria, representing data from 1593 root canal treatments, 1011 in non-diabetic control subjects, and 582 in diabetic patients. The calculated pooled odds ratio (OR = 1.42; 95 % CL = 1.11-1.80; p = 0.0058) indicates that diabetic patients have higher prevalence of RFT with RPLs than controls.

conclusionAvailable scientific evidence indicates that diabetes is significantly associated to higher prevalence of periapical radiolucencies in endodontically treated teeth, being an important putative pre-operative prognostic factor in RCT. CLINICAL RELEVANCE: Taking into account that diabetes is the third most prevalent chronic medical condition among dental patients, endodontic providers should be aware of the relationship between the outcome of endodontic treatment and diabetes.

Indexed as

Diabetes MellitusRoot Canal TherapyHumansPeriapical DiseasesPrevalenceDiabetes mellitusMeta-analysisPeriapical inflammationPersistent apical periodontitisRoot canal treatment outcomeRoot-filled teeth

Identifiers

PMID27055847
OpenAlexW2315415481

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.