ArticleEye (London, England)2016
The effect of topical anti-muscarinic agents on subfoveal choroidal thickness in healthy adults.
Article in Eye (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
- Clinical science effects of different mydriatics on retinal and choroidal parameters in healthy adults observed by widefield swept-source optical coherence tomography.BMJ open ophthalmology · 2025Trial
- Effects of tropicamide and compound tropicamide eye drops on ocular biological parameters and choroid thickness in children.BMC ophthalmology · 2025Trial
- Myopia Prevalence, Ocular Metrics and Visual Activity in United States Optometry Students.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Impact of Myopia Control Interventions on Choroidal Thickness in Children: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Ophthalmology science · 2026Review
- What is the relationship between the choroidal vascularity ındex (CVI) and myopia?International ophthalmology · 2025Article
- Choroidal thickness under pilocarpine versus cyclopentolate.Scientific reports · 2025Article
- Longitudinal Changes in Choroidal Thickness Varied With Refractive Progression in Myopic and Non-Myopic Children: A Two-Year Cohort Study.Investigative ophthalmology & visual science · 2024Article
- Autonomic Nervous System and Control of Visual Function.Annals of neurosciences · 2023Article
- IMI-The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia.Investigative ophthalmology & visual science · 2023Review
- SubFoveal Choroidal Imaging in High Myopic Nepalese Cohort.Journal of ophthalmology · 2023Article
- Choroidal Thickening During Young Adulthood and Baseline Choroidal Thickness Predicts Refractive Error Change.Investigative ophthalmology & visual science · 2022Article
- Effect of Intracameral Carbachol and Epinephrine Use on Choroidal Thickness After Uncomplicated Phacoemulsification.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Subfoveal scleral thickness is associated with peripheral retinal changes in high myopia in children and adolescents.International ophthalmology · 2022Article
- Choroidal and Retinal Thickness and Axial Eye Elongation in Chinese Junior Students.Investigative ophthalmology & visual science · 2021Observational
- The optic nerve head, lamina cribrosa, and nerve fiber layer in non-myopic and myopic children.Experimental eye research · 2020Article
- The human axial length and choroidal thickness responses to continuous and alternating episodes of myopic and hyperopic blur.PloS one · 2020Article
- Short-Term Effect of Low-Dose Atropine and Hyperopic Defocus on Choroidal Thickness and Axial Length in Young Myopic Adults.Journal of ophthalmology · 2019Article
- The effect of topical administration of cyclopentolate on ocular biometry: An analysis for mouse and human models.Scientific reports · 2017Article
- Longitudinal Choroidal Development in Preterm Infants.Ophthalmology scienceArticle
- The Influence of Topical Cyclopentolate Instillation on Peripapillary and Macular Microvasculature Measured by Optical Coherence Tomography Angiography in Healthy Individuals.Journal of current ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PurposeTo investigate the effects of tropicamide and cyclopentolate, which are two anti-muscarinic agents commonly used in the ophthalmologic practice, on subfoveal choroidal choroidal thickness (ChT) in healthy adults.MethodsA total of 74 healthy adult subjects were enrolled in the study. Subjects were randomly divided into two groups: (1) cyclopentolate group (n=37) in which the right eye (study eye) of each subject received topical cyclopentolate 1%, and the fellow eye (control eye) received artificial tears and (2) tropicamide group (n=37) in which the right eye (study eye) of each subject received topical tropicamide 1% and the fellow eye (control eye) received artificial tears. Each topical medication was applied three times with 10-min intervals. ChT measurements were performed at baseline and 40 min after the last drops of the topical medications by enhanced depth imaging (EDI) optical coherence tomography (OCT).ResultsIn the cyclopentolate group, subfoveal ChT significantly increased in the study eyes (P=0.013), whereas it did not significantly change in the control eyes (P=0.417). On the other hand, in the tropicamide group, no significant subfoveal ChT changes were observed in either the study eyes (P=0.715) or the control eyes (P=0.344).ConclusionsThe current study demonstrated that cyclopentolate caused significant choroidal thickening, whereas tropicamide had no significant effect on ChT in healthy adults. As a result, mydriasis by cyclopentolate may complicate ChT measurements by EDI OCT. Use of tropicamide may provide more reliable results for evaluation of ChT in ocular pathologies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.