ReviewInternational review of neurobiology2016
A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction.
Review in International review of neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Impact of adolescent social Isolation on increased risk for alcohol intake and aversion-resistant drinking in males and females.Research square · 2026Article
- Epigenetic Dysregulation in Alcohol-Associated Behaviors: Preclinical and Clinical Evidence.Current topics in behavioral neurosciences · 2025Review
- Effects of entinostat, quisinostat, and tubastatin-A on alcohol consumption in male high ethanol consuming rats.Frontiers in epigenetics and epigenomics · 2024Article
- Inhibitory and excitatory alcohol-seeking cues distinct roles in behavior, neurochemistry, and mesolimbic pathway in alcohol preferring (P) rats.Drug and alcohol dependence · 2023Article
- Adolescent alcohol and nicotine exposure alters the adult response to alcohol use.Advances in drug and alcohol research · 2023Review
- Modeling Aversion Resistant Alcohol Intake in Indiana Alcohol-Preferring (P) Rats.Brain sciences · 2022Article
- Predictive Value of Grooming Behavior for Development of Dermatitis in Selectively Bred P Rats as a Model of Trichotillomania Hair Pulling Disorder.Veterinary sciences · 2022Article
- Translational opportunities in animal and human models to study alcohol use disorder.Translational psychiatry · 2021Review
- Binge ethanol consumption-associated behavioral impairments in male mice using a gelatin-based drinking-in-the dark model.Alcohol (Fayetteville, N.Y.) · 2021Article
- A breeding strategy to identify modifiers of high genetic risk for methamphetamine intake.Genes, brain, and behavior · 2021Article
- Behavioral Profiles of Adolescent Alcohol-Preferring/Non-preferring (P/NP) and High/Low Alcohol-Drinking (HAD/LAD) Rats Are Dependent on Line but Not Sex.Frontiers in neuroscience · 2021Article
- Article
- Epigenetic changes on rat chromosome 4 contribute to disparate alcohol drinking behavior in alcohol-preferring and -nonpreferring rats.Alcohol (Fayetteville, N.Y.) · 2020Article
- Selective breeding for high alcohol preference is associated with increased sensitivity to cannabinoid reward within the nucleus accumbens shell.Pharmacology, biochemistry, and behavior · 2020Article
- Spontaneous Early Withdrawal Behaviors after Chronic 24-hour Free-Choice Access to Ethanol.Alcohol and alcoholism (Oxford, Oxfordshire) · 2020Article
- Co-administration of ethanol and nicotine heightens sensitivity to ethanol reward within the nucleus accumbens (NAc) shell and increasing NAc shell BDNF is sufficient to enhance ethanol reward in naïve Wistar rats.Journal of neurochemistry · 2020Article
- Conditioned stimuli affect ethanol-seeking by female alcohol-preferring (P) rats: the role of repeated-deprivations, cue-pretreatment, and cue-temporal intervals.Psychopharmacology · 2019Article
- An improved model of ethanol and nicotine co-use in female P rats: Effects of naltrexone, varenicline, and the selective nicotinic α6β2* antagonist r-bPiDI.Drug and alcohol dependence · 2018Article
- Article
- Alcohol-naïve USVs distinguish male HAD-1 from LAD-1 rat strains.Alcohol (Fayetteville, N.Y.) · 2018Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The purpose of this review is to present up-to-date pharmacological, genetic, and behavioral findings from the alcohol-preferring P rat and summarize similar past work. Behaviorally, the focus will be on how the P rat meets criteria put forth for a valid animal model of alcoholism with a highlight on its use as an animal model of polysubstance abuse, including alcohol, nicotine, and psychostimulants. Pharmacologically and genetically, the focus will be on the neurotransmitter and neuropeptide systems that have received the most attention: cholinergic, dopaminergic, GABAergic, glutamatergic, serotonergic, noradrenergic, corticotrophin releasing hormone, opioid, and neuropeptide Y. Herein, we sought to place the P rat's behavioral and neurochemical phenotypes, and to some extent its genotype, in the context of the clinical literature. After reviewing the findings thus far, this chapter discusses future directions for expanding the use of this genetic animal model of alcoholism to identify molecular targets for treating drug addiction in general.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.