ArticlePloS one2016
Structural Basis for Elastic Mechanical Properties of the DNA Double Helix.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A Study on the Bending Stiffness of a New DNA Origami Nano-Joint.Molecular biotechnology · 2021Article
- Mechanical Flexibility of DNA: A Quintessential Tool for DNA Nanotechnology.Sensors (Basel, Switzerland) · 2020Review
- Nanomechanical DNA resonators for sensing and structural analysis of DNA-ligand complexes.Nature communications · 2019Article
- Investigating the sequence-dependent mechanical properties of DNA nicks for applications in twisted DNA nanostructure design.Nucleic acids research · 2019Article
- Article
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Authors and funding
2 authors.
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Abstract
In this article, we investigate the principal structural features of the DNA double helix and their effects on its elastic mechanical properties. We develop, in the pursuit of this purpose, a helical continuum model consisting of a soft helical core and two stiff ribbons wrapping around it. The proposed model can reproduce the negative twist-stretch coupling of the helix successfully as well as its global stretching, bending, and torsional rigidities measured experimentally. Our parametric study of the model using the finite element method further reveals that the stiffness of phosphate backbones is a crucial factor for the counterintuitive overwinding behavior of the duplex and its extraordinarily high torsional rigidity, the major-minor grooves augment the twist-stretch coupling, and the change of the helicity might be responsible for the transition from a negative to a positive twist-stretching coupling when a tensile force is applied to the duplex.
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