Evidence map›Paper›PMID 27055193›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2016

Weight-Loss Diets, Adiponectin, and Changes in Cardiometabolic Risk in the 2-Year POUNDS Lost Trial.

Wenjie Ma, Tao Huang, Yan Zheng, Molin Wang, George A Bray, Frank M Sacks, Lu Qi

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

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  12. Influence of Weight Loss and Weight Regain on Adipose Tissue Inflammation.Arteriosclerosis, thrombosis, and vascular biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Wenjie MaDepartments of Epidemiology (W.M., M.W., L.Q.) and Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, and Channing Division of Network Medicine (L.Q.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115; Department of Epidemiology (T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; and Pennington Biomedical Research Center of the Louisiana State University System (G.A.B.), Baton Rouge, Louisiana 70808.
Tao HuangDepartments of Epidemiology (W.M., M.W., L.Q.) and Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, and Channing Division of Network Medicine (L.Q.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115; Department of Epidemiology (T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; and Pennington Biomedical Research Center of the Louisiana State University System (G.A.B.), Baton Rouge, Louisiana 70808.
Yan ZhengDepartments of Epidemiology (W.M., M.W., L.Q.) and Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, and Channing Division of Network Medicine (L.Q.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115; Department of Epidemiology (T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; and Pennington Biomedical Research Center of the Louisiana State University System (G.A.B.), Baton Rouge, Louisiana 70808.
Molin WangDepartments of Epidemiology (W.M., M.W., L.Q.) and Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, and Channing Division of Network Medicine (L.Q.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115; Department of Epidemiology (T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; and Pennington Biomedical Research Center of the Louisiana State University System (G.A.B.), Baton Rouge, Louisiana 70808.
George A BrayDepartments of Epidemiology (W.M., M.W., L.Q.) and Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, and Channing Division of Network Medicine (L.Q.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115; Department of Epidemiology (T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; and Pennington Biomedical Research Center of the Louisiana State University System (G.A.B.), Baton Rouge, Louisiana 70808.
Frank M SacksDepartments of Epidemiology (W.M., M.W., L.Q.) and Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, and Channing Division of Network Medicine (L.Q.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115; Department of Epidemiology (T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; and Pennington Biomedical Research Center of the Louisiana State University System (G.A.B.), Baton Rouge, Louisiana 70808.
Lu QiDepartments of Epidemiology (W.M., M.W., L.Q.) and Nutrition (Y.Z., F.M.S., L.Q.), Harvard T.H. Chan School of Public Health, and Channing Division of Network Medicine (L.Q.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115; Department of Epidemiology (T.H., L.Q.), School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112; and Pennington Biomedical Research Center of the Louisiana State University System (G.A.B.), Baton Rouge, Louisiana 70808.
Harvard University · USLouisiana State University System · USTulane University · US

Funding

Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0M
RISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8M
Common Genetic Variation and Quantitative Diabetes TraitsR01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2008 to 2014
$5.0M
Genetic Markers of CHD in Type 2 DiabetesR01HL071981 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI QI, LU · 2003 to 2012
$4.9M
Obesity Genes, Energy Regulation in Response to Weight-Loss DietsR01DK091718 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2012 to 2021
$4.5M
Weight-Loss Diet Intervention on Cardiometabolic Factors of Gut MicrobiotaR01DK100383 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2014 to 2024
$4.2M
Rare Sequence Variation and Diabetes Quantitative TraitsU01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2015 to 2019
$3.6M
Genome-wide interactions with diet patterns on long-term weight changeR21HL126024 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2015 to 2016
$421k
NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL071981NHLBI NIH HHS R21 HL126024NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK091718NIDDK NIH HHS R01 DK100383NIDDK NIH HHS U01 DK078616
6 · The paper itself

Abstract

contextCompelling evidence suggests that the beneficial effects of weight-loss diet interventions on improvement of cardiometabolic risk factors may be partly through modulating secretion of adiponectin from adipose tissue.

objectiveTo investigate the effects of long-term weight-loss diets with different compositions of macronutrients on longitudinal changes in circulating adiponectin concentrations and how such changes, if they exist, affect cardiometabolic risk. DESIGN, SETTING, AND

participantsIn the 2-year Preventing Overweight Using Novel Dietary Strategies trial, 811 overweight or obese adults were randomly assigned to 1 of 4 diets varying in macronutrient intakes. The current analysis was restricted to participants who had baseline adiponectin measurement (n = 768). Circulating concentrations of adiponectin and cardiometabolic outcomes were repeatedly measured at baseline, 6 months, and 2 years.

main outcome measuresCirculating concentrations of adiponectin and cardiometabolic risk factors.

resultsWeight-loss diet interventions significantly increased circulating adiponectin concentrations over 2 years, similarly in 4 diet groups (P value for difference >.05). We found that the increase of adiponectin was significantly associated with reduction of waist circumference and low-density lipoprotein cholesterol, but associated with increase of high-density lipoprotein cholesterol (P < .001 for each), after adjusting for age, sex, ethnicity, follow-up time, diet group, baseline body mass index, baseline level of respective outcome trait, and concurrent weight change.

conclusionsOur findings indicate that long-term interventions by weight-loss diets varying in macronutrients similarly increase circulating adiponectin, which may particularly improve abdominal fat distribution and lipid metabolism independently of weight change.

Indexed as

Diet, ReducingAdiponectinAdultBody Mass IndexCardiovascular DiseasesFemaleHumansMaleMetabolic DiseasesMiddle AgedObesityOverweightRisk FactorsTreatment OutcomeWaist CircumferenceWeight LossAdiponectin

Identifiers

PMID27055193
PMCPMC4891796
OpenAlexW2319392544

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.